Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm test #1 > Sulfonamides > Flashcards

Sulfonamides Flashcards

1
Q

bactrim is used for what 2 things in men?

A

UTI/ Prostatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

sulfomanides can cause _____ in pts with G6PDH def?

A

hemolytic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Sulfomanides are CI in which group? Why?

A

new borns/infants, pregnant females increased risk for Kernicterus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is polytrim used for?

A

bacterial conjunctivitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Bactrim is used to treat gastroenteritis caused by what 2 bugs?

A

Salmonella and shigella

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the role of Trimethoprim in bactrim/sulfatrim?

A

inhibit conversion of dihydrofolate to tetrahydrofolate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Sulfonamides are higly bound to albumin, they can displace other drugs like ______, leading to an increase in serum concentration of free blood

A

warfarin and methotrexate (increased bleeding)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

sulfasalazine has anti-inflammatory uses beneficial for what 3?

A
  1. ulcerative colitis 2. colitis 3. juvenule rheumatoid arthritis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

bactrim is DOC for what 2 disease and their bugs?

A
  1. Nocardia- pulmonary lesions 2. Pneumocystitis jiroveci- PNA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

bactrim is first line for otitis, sinusitis, and PNA caused by what 2?

A

H. Flu and M. Catarrhalis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the indication of Sulfisoxazole acetyl and Erythromycin?

A

Otitis media in children (H. Flu)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the use of Mafenide?

A

topical for preventing burn infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Does cross resistance exists among sulfonamides?

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the use for silver sulfadiazine?

A

topical to prevent burn infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is mechanism of action of Trimethoprim?

A

inhibitor of dihydrofolate reductase which reduces tetrahydrofolate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Is sulfasalazine absorbed in the GI tract?

A

no

17
Q

What is the abx spectrum of sulfonamides?

A

many gram pos and gram neg

18
Q

What is the indication of sulfamethoxazole and Trimethoprim (bactrim)?

A

synergistic abx actions

19
Q

What are the 3 uses of Sulfacetamide?

A

topical for 1. ocular infections 2. acne 3. bacterial skin infections

20
Q

Trimethoprim causes folate def, therefore leading to what 3 things? Can be treated with?

A
  1. megaloblastic anemia 2. leukopenia 3. granulocytopenia Folinic acid
21
Q

WHy must you drink lots of water when taking sulfonamides?

A

It can cause crystalluria and nephrotoxicity

22
Q

Trimethoprim is good at treating what 2 things?

A
  1. UTI 2. bacterial prostatitis
23
Q

What is Kernicterus?

A

increased bilirubin in the CNS

24
Q

What is the MOA of sulfonamides?

A
  1. They inhibit the synthesis of bacterial folic acid 2. they compete with PABA for dihydropteroate synthetase, thereby inhibiting the incorporation of PABA into bacterial folic acid.
25
Q

What is the indication of sulfadiazine and pyrimethamine?

A

Toxoplasmosis

26
Q

PCN and sulfomamides can both cause what?

A

hypersensitivity reactions

Pharm test #1 (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions