FQ Flashcards

1
Q

What are the 2 most popular FQ’s?

A
  • Levoflaxin (3rd gen) - ciproflaxin (2nd gen)
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2
Q

4th generation FQs can treat? what 3 are added?

A

anerobic gram pos Bacteroides fragilis, Fusobacterium, Peptostreptococcus

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3
Q

What is the MOA?

A

Interfere with bacterial DNA replication, transcription, and repair through inhibition of DNA gyrase

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4
Q

Ofloxacin can treat the same as cipro PLUS?

A

Urethritis from chlamydia trachomatis

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5
Q

Which 3 drugs can enter intracellular organisms?

A

Tetracyclines, FQ, and macrolides

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6
Q

Do not take FQs with……

A

antacids, dietary supplements

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7
Q

What effects does FQ’s have on tendons?

A

Can cause tendonitis and tendon rupture (achilles)

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8
Q

Linezolid is effective against which 8 bacteria?

A
  1. MRSA 2. VISA 3. VRSA 4. VRE- Enterococcus Faecium 5. VRE- enterococcus Faecalis 6. MDRSP 7. strep pyogenes 8. strep agalactiae
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9
Q

Synercid: route? SE?

A

IV Infusion phlebitis; interacts with certain medications

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10
Q

SE of Linezolid?

A

Myelosuppression, reversible anemia, and thrombocytopenia

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11
Q

Which FQ is safe in pts with decreased renal function?

A

Moxifloxacin

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12
Q

Methenamine mandelate and methenamine hippurate: action? route? SE? CI?

A

urinary tract antiseptics ( turns into formaldehyde) PO GI upset, hematuria, skin rash CI in liver/renal failure and along with sulfonamides

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13
Q

What effects do FQs have on the heart?

A

can prolong the QT interval

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14
Q

Cipro is used for what HEENT dz?

A

otitis externa

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15
Q

What is the mechanisms of 3rd and 4th gen FQ’s?

A

inhibit topoisomerase IV

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16
Q

Linezolid is only effective against what type of bacteria?

A

gram pos

17
Q

Cipro is used to tx Prostatisit of what 4 bugs?

A
  1. E. coli 2. Proteus 3. Klebsiella 4. Pseudomonas KEPP
18
Q

what are 3 reasons why you would choose Linezolid over Synercid?

A
  1. to treat PNA 2. both forms for entercoccus 3. given orally
19
Q

Cipro is used for what eye dzs?

A

bacterial conjuctivitis and corneal ulcers

20
Q

Synercid is effective against what bacteria?

A
  1. VRA 2. MRSA 3. VISA 4. VRSA 5. step pyogenes
21
Q

Cipro is used to treat RTI of what 4 bugs?

A
  1. Moraxella 2. Haemophilus 3. Pseudomonas 4. Klebsiella
22
Q

Which 5 FQ’s are used to treat MDRSP?

A
  1. Moxifloxacin 2. Levoflaxin 3. Gemifloxacin 4. Gatifloxacin 5. Besifloxacin
23
Q

Cipro is used to tx UTI’s of what 6 bugs?

A
  1. Enterococcus 2. E. COli 3. Enterobacter 4. Proteus 5. Pseudomonas 6. Klesiella KEEEPP
24
Q

Nitrofurantoin: action? MOA? active against what 2 bugs? route? SE? CI?

A

urinary tract antiseptic (most common) damages bacterial DNA (prodrug) E.Coli and staph saprophyticus PO turns the urine brown, GI upset, rash, photosensitivy, anemia SI in RF, neonates, and pregnancy

25
Q

What 3 bugs are intracellular organisms?

A

Legionella, Chlamydia, Mycoplasma

26
Q

3rd generation FQs can treat? what 4 are added?

A

gram pos and gram neg Staph aureus, step pneumo, MDRSP, strep pyogenes

27
Q

All FQ’s are effective against what?

A

gram neg organisms

28
Q

What efect do FQs have on sun exposure?

A

increased photosensitivity

29
Q

FQs are CI in which group?

A

pregnancy, nursing mothers, children under 18,

30
Q

Gemifloxacin is commonly used for what 2?

A
  1. PNA 2. Bronchitis