FQ

Question 1

What are the 2 most popular FQ’s?

Answer 1

• Levoflaxin (3rd gen) - ciproflaxin (2nd gen)

Question 2

4th generation FQs can treat? what 3 are added?

Answer 2

anerobic gram pos Bacteroides fragilis, Fusobacterium, Peptostreptococcus

Question 3

What is the MOA?

Answer 3

Interfere with bacterial DNA replication, transcription, and repair through inhibition of DNA gyrase

Question 4

Ofloxacin can treat the same as cipro PLUS?

Answer 4

Urethritis from chlamydia trachomatis

Question 5

Which 3 drugs can enter intracellular organisms?

Answer 5

Tetracyclines, FQ, and macrolides

Question 6

Do not take FQs with……

Answer 6

antacids, dietary supplements

Question 7

What effects does FQ’s have on tendons?

Answer 7

Can cause tendonitis and tendon rupture (achilles)

Question 8

Linezolid is effective against which 8 bacteria?

Answer 8

1. MRSA 2. VISA 3. VRSA 4. VRE- Enterococcus Faecium 5. VRE- enterococcus Faecalis 6. MDRSP 7. strep pyogenes 8. strep agalactiae

Question 9

Synercid: route? SE?

Answer 9

IV Infusion phlebitis; interacts with certain medications

Question 10

SE of Linezolid?

Answer 10

Myelosuppression, reversible anemia, and thrombocytopenia

Question 11

Which FQ is safe in pts with decreased renal function?

Answer 11

Moxifloxacin

Question 12

Methenamine mandelate and methenamine hippurate: action? route? SE? CI?

Answer 12

urinary tract antiseptics ( turns into formaldehyde) PO GI upset, hematuria, skin rash CI in liver/renal failure and along with sulfonamides

Question 13

What effects do FQs have on the heart?

Answer 13

can prolong the QT interval

Question 14

Cipro is used for what HEENT dz?

Answer 14

otitis externa

Question 15

What is the mechanisms of 3rd and 4th gen FQ’s?

Answer 15

inhibit topoisomerase IV

Question 16

Linezolid is only effective against what type of bacteria?

Answer 16

gram pos

Question 17

Cipro is used to tx Prostatisit of what 4 bugs?

Answer 17

1. E. coli 2. Proteus 3. Klebsiella 4. Pseudomonas KEPP

Question 18

what are 3 reasons why you would choose Linezolid over Synercid?

Answer 18

1. to treat PNA 2. both forms for entercoccus 3. given orally

Question 19

Cipro is used for what eye dzs?

Answer 19

bacterial conjuctivitis and corneal ulcers

Question 20

Synercid is effective against what bacteria?

Answer 20

1. VRA 2. MRSA 3. VISA 4. VRSA 5. step pyogenes

Question 21

Cipro is used to treat RTI of what 4 bugs?

Answer 21

1. Moraxella 2. Haemophilus 3. Pseudomonas 4. Klebsiella

Question 22

Which 5 FQ’s are used to treat MDRSP?

Answer 22

1. Moxifloxacin 2. Levoflaxin 3. Gemifloxacin 4. Gatifloxacin 5. Besifloxacin

Question 23

Cipro is used to tx UTI’s of what 6 bugs?

Answer 23

1. Enterococcus 2. E. COli 3. Enterobacter 4. Proteus 5. Pseudomonas 6. Klesiella KEEEPP

Question 24

Nitrofurantoin: action? MOA? active against what 2 bugs? route? SE? CI?

Answer 24

urinary tract antiseptic (most common) damages bacterial DNA (prodrug) E.Coli and staph saprophyticus PO turns the urine brown, GI upset, rash, photosensitivy, anemia SI in RF, neonates, and pregnancy

Question 25

What 3 bugs are intracellular organisms?

Answer 25

Legionella, Chlamydia, Mycoplasma

Question 26

3rd generation FQs can treat? what 4 are added?

Answer 26

gram pos and gram neg Staph aureus, step pneumo, MDRSP, strep pyogenes

Question 27

All FQ's are effective against what?

Answer 27

gram neg organisms

Question 28

What efect do FQs have on sun exposure?

Answer 28

increased photosensitivity

Question 29

FQs are CI in which group?

Answer 29

pregnancy, nursing mothers, children under 18,

Question 30

Gemifloxacin is commonly used for what 2?

Answer 30

1. PNA 2. Bronchitis