FQ Flashcards
What are the 2 most popular FQ’s?
- Levoflaxin (3rd gen) - ciproflaxin (2nd gen)
4th generation FQs can treat? what 3 are added?
anerobic gram pos Bacteroides fragilis, Fusobacterium, Peptostreptococcus
What is the MOA?
Interfere with bacterial DNA replication, transcription, and repair through inhibition of DNA gyrase
Ofloxacin can treat the same as cipro PLUS?
Urethritis from chlamydia trachomatis
Which 3 drugs can enter intracellular organisms?
Tetracyclines, FQ, and macrolides
Do not take FQs with……
antacids, dietary supplements
What effects does FQ’s have on tendons?
Can cause tendonitis and tendon rupture (achilles)
Linezolid is effective against which 8 bacteria?
- MRSA 2. VISA 3. VRSA 4. VRE- Enterococcus Faecium 5. VRE- enterococcus Faecalis 6. MDRSP 7. strep pyogenes 8. strep agalactiae
Synercid: route? SE?
IV Infusion phlebitis; interacts with certain medications
SE of Linezolid?
Myelosuppression, reversible anemia, and thrombocytopenia
Which FQ is safe in pts with decreased renal function?
Moxifloxacin
Methenamine mandelate and methenamine hippurate: action? route? SE? CI?
urinary tract antiseptics ( turns into formaldehyde) PO GI upset, hematuria, skin rash CI in liver/renal failure and along with sulfonamides
What effects do FQs have on the heart?
can prolong the QT interval
Cipro is used for what HEENT dz?
otitis externa
What is the mechanisms of 3rd and 4th gen FQ’s?
inhibit topoisomerase IV