Sulfanomides

Question 0

DHFR reductase is 1) inhibited by and 2) converts what to what?

Answer 0

TMP (Trimethoprim)

2) dihydrofolic acid to tetrahydrofolic acid (then to DNA/RNA -> stops protein synthesis)

Question 1

DHFR synthase 1) converts what to what and 2) is inhibited by what?

Answer 1

1) PABA to dihydrofolic acid

2) inh by SMX/sulfanomides

Question 2

Bactrim/TMP-SMX is DOC for

Answer 2

UTI

Question 3

Spectrum of bactrim/TMP-SMX

Answer 3

G+/G-

Question 4

crosses placenta and BBB

excreted in breast milk so avoid near term and in nursing prematures or jaundiced infants

Answer 4

bactrim/TMP-SMX

Question 5

bactrim/TMP-SMX is excreted through

Answer 5

kidney

Question 6

sulfazaline is

Answer 6

a prodrug:

ulcerative colitis and RA

Question 7

Steven-Johnsons is SE in

Answer 7

bactrim/TMP-SMX

Question 8

cross sensitivity with other sulfa drugs

Answer 8

bactrim/TMP-SMX

Question 9

kernicterus (what is it?) with

Answer 9

bactrim/TMP-SMX

void pregs and <2 months

Question 10

photosensitivity is with

Answer 10

bactrim/TMP-SMX

Question 11

which drug is an alternative to Vanco (txs serious G+) and has no resistance?

Answer 11

Daptomycin

lipopeptide

Question 12

Daptomycin is a

Answer 12

lypopeptide

Question 13

Binds to bacterial membrane, forms channels: leakage of ion depolazises membrane and inhibits protein, DNA and RNA synthesis

Answer 13

Daptomycin

Question 14

treats G+: MRSA, MSSA, aerobs and unaerobs

Answer 14

Daptomycin

Question 15

IV once daily

Answer 15

daptomycin

excreted kidney

Question 16

Mupirocin (Bactroban) spectrum:

Answer 16

good G+/some G-
static at low [ ]/cidal at high [ ]
Impetigo by S Aureus or strep pyogenes
MRSA - intranasal

Question 17

no cross sensitivity with

Answer 17

Mupirocin/Bactroban

Question 18

which drug treats impetigo

Answer 18

bactroban/mupirocin

Question 19

MOA of bactroban/mupirocin:

Answer 19

inhibits protein and RNA synthesis by irreversably binding to iso…tRNA synthase

Question 20

Binds to G- bacterial cell membrane phospolipids (LIPID A of endotoxin): increases permiability and decreases metabolites, cell doesn’t survive

Answer 20

Polymyxin B

Question 21

Lipid A is only found in what type of bacteria

Answer 21

G-

Question 22

What binds to Lipid A of G- bacteria

Answer 22

Polymyxin B

Question 23

cidal against most G- bacilli except Proteus and Neisseria

no effect on G+

Answer 23

Polymyxin B

Question 24

polypeptide ABs:

Answer 24

polymyxin B and Colistin (polymyxin E)

Question 25

Never used orally or parenterally

Answer 25

polymyxin B or Colistin bc

NEPHROTOXIC

Question 26

with neomycin (G-?) and bacitracin (G+?)

Answer 26

polynyxin B and Colistin

Question 27

Colistin

Answer 27

Polymyxin B

Question 28

Polymyxin B aka

Answer 28

Colostin

Question 29

Mupirocin

Answer 29

Bactroban