DOC

Question 0

Neisseria miningitis

Answer 0

Pen G (G - cocci)

Question 1

Neisseria gonorrhoeae (G - cocci)

Answer 1

Ceftriaxone or (cefpodoxime ?)

Question 2

E Coli, Klebsiella, Proteus (G - rod O2)

Answer 2

1st or 2nd gen cephalosporin (Cefazolin or Cefaclor) OR

TMP-SMZ (bactrim)

Question 3

Enterobacter, Citrobacter, Serratia (G- rods O2)

Answer 3

TMP-SMZ (bactrim - UTI), quinolone, carbapenem

Question 4

DOC for UTI

Answer 4

1) DOC is bactrium TMP-SMZ
2) Cipro (x pregs/kids)
3) methamine if pregs/kid(UTI drug, not Nitro bc x pregs, 4 mo) OR
(if not pregs/kid: nitrofurantoin?, then if not pregs, why skip Cipro?)

Question 5

Helicobacter pylori (G- rods O2)

Answer 5

BISMUTH+ METROnidazole and tetra or amoxicillin

Question 6

Vibrio (Cholera)

Answer 6

Tetracycline

Question 7

Pseudomonas Aeruginosa (G- rod O2)

Answer 7

AP pen (gr4) + aminoglycoside

Question 8

Legionella (G- rod O2)

Answer 8

Azithromycin (macrolide 50S) + rifampin or

quinolone + rifampin

Question 9

Strep pneumoniae (G + cocci)

Answer 9

Penicillin

Question 10

Strep pyogenes (G+ cocci)

Answer 10

Pen or clindamycin

Question 11

B-lactamase negative Staph Aureus (G+ cocci)

Answer 11

Penicillin

Question 12

B-lactamase positive Staph Aureus (G+ cocci)

Answer 12

Pen resistant penicillin (gr 2)

Question 13

MRSA

Answer 13

Vanco

Question 14

Enterococcus (G + cocci)

Answer 14

Pen +/- amino

Question 15

Listeria (G + rod)

Answer 15

Ampicilline +/- amino

Question 16

C Diff (- O2)

Answer 16

Metronidazole (-02 only!)

Question 17

Cryptococcus

Answer 17

Amphotericin B (no CNS) +/- flucytosine (5FC) (goes to CNS)

Question 18

Candida

Answer 18

Amph B + caspofungin

Question 19

Aspergillus (fungus)

Answer 19

Amph B + Voriconazole

Question 20

Chlamydia

Answer 20

Tetra or macrolide

Question 21

mycoplasma pneumoniae

Answer 21

tetra or erythromycin (macrolide)

Question 22

Mycobacterium Leprae

Answer 22

Dapson + rifampin

Question 23

mycobacterium TB

Answer 23

isoniazid + rifampin (replace with ______ if renal/liver dysfx or if HIV?) + ethambutol (narrow) + pyrazinamide

Question 24

drugs that treat G+ only

Answer 24

Vanco, bacitracin, Daptomycin

Question 25

Drugs that treat G - only

Answer 25

Aztreonam, Polymyxin B, (Aminos?)

Question 26

drugs that treat AEROBIC only?

Answer 26

Aztreonam, Cipro/quinolones (exc moxi, gemi), AMINOS

Question 27

Drugs that treat anaerobic bacteria only?

Answer 27

Metronidazole

Question 28

Clindomycin is DOC for

Answer 28

``` Strep pyogenes (or pen) osteomylitis ```

Question 29

Ampicillin is DOC for

Answer 29

Listeria (+/- aminos)

Question 30

Tetracycline is DOC for

Answer 30

Vibrio (Cholera) Mycobacteria Pneumonia (or erythro (macrolide) Chlamydia (or macrolide: azithro/erythro H Pylori (Bismuth+Metro and either tetracycline or amoxicillin) B. burgdorferi (Lyme Dz) (or ceftriaxone)

Question 31

Drugs that should be avoided in pregs and kids

Answer 31

1) tetracyclines (<2mo, CNS) | 4) Dalfopristin/Quinupristin (kids)

Question 32

Drugs with high drug interaction

Answer 32

Dalfopristin/QUinupristin | Erythromycin (highest), azithromycin (lowest)

Question 33

SE of bone marrow depression, gray baby and fatal aplastic anemia

Answer 33

CLORamphenicol

Question 34

SE of tendon rupture

Answer 34

CIRPO (quinolones)

Question 35

broad and wide spectrum drugs

Answer 35

``` chloramphenicol cefepime (4th gen cephalosporin) 3rd gen cephalosporins Methanamine (broad, esp G-) Nitrofurantoin (wide) Cipro (broad or wide) tetracyclines (and tige(r)cycline) Telithromycin (ketolide - similar to macrolides) clindamycin (wide) Fosfomycin (wide) Imipenem + meropenem (broad and AP) Entrapenem (wide - AP) ```

Question 36

drugs administered orally

Answer 36

``` Pen V (natural( Oxacilline (pen resistant Gr2) Cefixime (3rd gen cephalosporin) Cipro (quinolone) Levofloxacin (quinolone) Bactrim (oral, parenteral) Metronidazole (oral, IV, topical) ```

Question 37

CefOTAXime

Answer 37

3rd gen cephalosporin | CNS

Question 38

CeftAZIDime

Answer 38

3rd gen cephalosporin | AP, no CNS

Question 39

CefIXime

Answer 39

3rd gen cephalosporin | no AP, no CNS but ORAL!

Question 40

CefUROxime

Answer 40

2nd gen cephalosporin

Question 41

Does cefepime have AP?

Answer 41

Yes

Question 42

CefPROzil

Answer 42

2nd gen cephalosporin

Question 43

B.Burgdorgeri (Lyme Dz)

Answer 43

doxycycline or amoxicillin or ceftriaxone

Question 44

Mycobacterium Avium

Answer 44

Clarithro/Azithro(macrolides) + ethumbutol + rifambutin/refampin/cirpo (quinolones) +/- amikacin (amino)

Question 45

Nocardia (not sure will be asked)

Answer 45

TMP-SMX (bactrim) or sulfadiazine

Question 46

Aspergillus

Answer 46

Voriconazole + Amph B

Question 47

CAndida

Answer 47

CAspofungin + Amph B | GI candida and topical Primarily treated by NYSTATIN!

Question 48

Cryptococcus

Answer 48

Amph B (no CNS) +/- Flucytosine (goes to CNS)

Question 49

1) Invasive ASPergillus (in retractive pts) is treated by | 2) Non invasive Aspergillus is treated by

Answer 49

1) cASPofungin | 2) Voriconazole + Amph B

Question 50

Moxarella

Answer 50

TMP or Cephalospon gen 2 or 3!! (not gen 1 or 2 which is E. coli, Kleb, Proteus (along with TMP))

Question 51

Mycobacterium Leprae

Answer 51

Dapsone + rifampin | do we need to diff multi ( clofazimine-didn't cover this one?)) or paucibacillary?

Question 52

Lyme Dz

Answer 52

doxycycline (tetra - don't use if pregs/kid) or amoxicillin (pen 3) or ceftriaxone (don't use if allergy to pens)