Fluoroquinolones and UTI drugs Flashcards
DOC for UTI
bactrim (TMP)
Which strains cause UTI
E Coli (most), Klesiela and Proteus Proteus increases pH (less acidic) and decreases activity of many UTI drugs
MOA of fluoroguinolones
inhibit DNA gyrase -> can’t transcribe and replicate -> CIDAL
(also Topo IV - can’t separate chromosomes into dtr cells)
Ciprofloxacin is DOC for
anthrax prophylaxis
Cipro/quinolones spectrum
G- rods (enterobacter citrobacter, serratia, neisseria)
G+ MRSA
AEROBIC (except Moxi and Gemi)
+AP (all)
SE of Cipro
GI (if diarrhea use erythromycin)
increased QT interval (fatal)
tendon rupture and cartilage erosion - don’t use in pregs and kids< 18 yo
which drug increases QT interval?
Cirpo
which drug causes tendon rupture and cartilage erotion
Cipro
which is aerobic only
cipro
+AP
contraindicated in pregs and kids < 18 yo
cipro due to tendon rupture and cartilage erotion
which drugs tx prostatitis?
Norfloxacin and Ogloxacin
which fluoroquinolones fight an?aerobic bacteria?
moxifloxacin and gemifloxacin
which fluoroquinolones fight penicillin-resistant strep. pneumonia?
moxifloxacin and gemifloxacin
which drug fights G+/G- anaerobs only?
Metronizadole
DOC for pseudomembranous colitis
Metronizadole
caused by C. Diff, DOC for C Diff is Metronizadole
Metronizadole MOA
prodrug: once metabolized by bacteria, it’s taken up into DNA -> CIDAL
Metronizadone SE
Candida superinfection
hypersensitivity
(ask prof if any more?)
If creatinine is < 50 ml/min don’t use which drug? (renal failure)
Nitrofurantoin
Nitrofurantoin is DOC for
Nothing - not UTI, use as alternative if bactrim resistance
which drug is static and cidal?
Nitrofurantoin
NITROfurantion MOA
Prodrug: damage to DNA -> don’t really know what it does -> Static and CIDAL
NITROfurantoin spectrum
G+/G- (E.Coli, S pyogenes, citrovacter, klebsiella, enterobacter, salmonella, shigella
Proteus and Pseudomonas are resistant
- AP
which drug causes hymolytic anemia
NITOfurantoin
G6PD
Which drug causes interstitial pulmonary fibrosis?
NITROfurantoin