Macrolides

Question 0

Which drug doesn’t cover G-

Answer 0

Erythromycin

most G- resistant to it

Question 1

Macrolides inhibit which ribosome?

Answer 1

Inhibit 50S ribosome and inhibit protein synthesis

Question 2

DOC for erythromycin

Answer 2

Clamydia

Question 3

Clarithromycin DOC

Answer 3

Legionella

Question 4

What is azithromycin (z pack) DOC for?

Answer 4

ask prof

Question 5

which drug goes through biliary excretion (fecal elimination)?

Answer 5

Macrolides: erythromycin, clarithromycin, azithromycin

Question 6

reversible non-selective inhibitor of MAO

Answer 6

Linezolid (Zyvox)

Question 7

reserved for MDR strains, overuse can increase resistance of MDRS

Answer 7

Linezolid (Zyvox)

Question 8

no cross-resistance

Answer 8

Zyvox (Linezolid)

Question 9

primarily aerobic G+

Narrow

Answer 9

linezolid (zyvox)

Question 10

binds to 23S ribosomal RNA of 50 S subunit

Answer 10

linezolid (zyvox)

Question 11

metabolized by CYP3A4 (P450) in liver

Answer 11

thelithromycin

Question 12

ketolides are

Answer 12

thelithromycin
clindamycin
Dalfopristin
quinupristin (IV)

Question 13

Broad spectrum, static

against respriratory erythro and pen resistant pneumococci

Answer 13

thelithromycin

Question 14

SE of diarrhea and hepatotoxic

Answer 14

thelithromycin

Question 15

admin route for thelithromycin

Answer 15

oral

Question 16

wide G+ cocci, anaerobic G- and G+

DOC for osteomylitis

Answer 16

clindamycin

bc high [ ] in bones

Question 17

which drug causes psudomembranous colitis

Answer 17

clindamycin

overgrowth of C. Diff - DOC is metronidazole

Question 18

clindomycin is DOC for

Answer 18

osteomylitis

Question 19

is clindomycin cidal or static?

Answer 19

both, depends on [ ]

Question 20

which drug crosses placenta and should be avoided during nursing?

Answer 20

clindamycin

Question 21

if suspect toxic shock while using vanco - which drug should you switch to ?

Answer 21

clindamycin

Question 22

low in CSF but used for toxoplasma encephilitis (not meningitis)

Answer 22

clindamycin

Question 23

which 2 drugs are members of streptogramins

Answer 23

Dalfopristin and quinupristin (IV)

Question 24

which 2 drugs are cidal together (IV) and static apart? (synergy)

Answer 24

Dalfopristin and quinupristin (IV)

Question 25

SE of dalfopristin and quinupristin

Answer 25

hepatotoxic
inhibits P450 (cyp3A4)

Question 26

which drug inhibits early phase of protein synthesis by blocking ribosome 50?

Answer 26

Dalfopristin

Question 27

which inhibits late phase of protein synthesis by blocking ribosome 50?

Answer 27

quinupristin

Question 28

treats vanco resistant Enterococcus faecium,
penicillinase resistant s. pneumoniae (strep pn?)
MDR streptococci
MRSA and MSSA
s. epidermis

Answer 28

Dalfopristin and quinupristin (IV)

pen resistant strep pneumoniae is also tx’d by fluoroquinolone: moxi and gemifloxacin

Question 29

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ask prof: is erythromycin DOC for clamydia or Azythro and tetracycline?

Answer 29

???????????????????????

Question 30

spectrum of erythromycin

Answer 30

mostly G+

similar to Pen G

Question 31

which drugs are macrolides

Answer 31

erythromycin (oral, IV)
clarithromycin oral
azithromycin (z pack) oral, IV

Question 32

MOA of erythromycin and clarithro/azithro

Answer 32

revesibly bind to 50S ribosomal subunit

Question 33

SE of IV erythromycin

Answer 33

ototoxicity

Question 34

SE of erythromycin

Answer 34

lots of GI, diarrhea

hepatic (liver) changes (juandice, abnormal liver)

Question 35

potent inhibitor of CYP3A4 -> lots of drug interactions

Answer 35

erythromycin:

inhibits hepatic metabolism of other drugs that need CYP3A4 -> increases other drug’s serum [ ] leading to toxicity

Question 36

which of 3 macrolides has most GI and least GI side effects

Answer 36

most - erythromycin

least - clarithromycin

Question 37

which has prolonged QT and arrythmias due to drug interactions:

Answer 37

erythromycin

(azithro has the least heart SE among 3)

(Cipro (quinolone) also increases QT interval)