structure of drugs Flashcards
why is a shape and chirality important for pharmacist
this is because our protiens are made up of amino acis and we are all chirals
dna is also chiral
history of thalidomide?
it was widely prescribed for morning sickness only outside of USA, however it was found to be serious teratogenic as it caused alot of defects in around 10,000 babies.
it was being sold as racemic mixture of the two enantiomers which is why the unwanted effects
and thus why it was unsafe for pregnant women.
what is the formula for ethane
ch3ch3
how many carbons in meth,eth,prop,but,pent,hex,hept,oct
1
2
3
4
5
6
7
8
what is the bond angle o=c=o
180degrees
bond angle in c-h-h-h-h
109.5
what are conformers
they used thermal energy to rotate single bonds in a molecule ususally explained by newmans projection
tricks for chrirocentre
ignore chs 3 groups at the end
ignore ch2 groups
ignore double-tripled bons
what is a chiral
this is when a carbon is bonded to 4 different groups
what are steroisomers
they have the same molecular formula but a different structure
what is a constitutional isomers
connected different and have have different carbons
what is a enantiomers?
they have a mirror image
and all of the chiroocentres must changes
what is a diastereomer?
the first chiro centre remains the same and the second one changes
this is when some of the chirocentres change but not all of them
what is a meso compound?
they have a line of symmetry
they are identical molecule and can never be enantiomers
what is cis /trans
cis = same side
trains = opposite side
