Stress (weeks 1 & 2) Flashcards
What is stress?
-response to a threat
-leads to disruption in homeostasis
Types of stress
-physical
-psychological
-environment/cellular
Allostasis
-the body’s adaptive response to stress
-the body is rarely in a state of homeostasis
Examples of Allostasis
-exposure to cold temperature causing shivering
-the body releasing insulin after a rise in blood glucose levels
Stressors
-the actual threat that challenges the body’s internal balance
types:
-physical: acute injury, infection, temperature change, poor diet, bad posture, inadequate sleep
-psychological: financial hardships, family conflict, unemployment, toxic work, excessive workload
-environment/cellular: damage to proteins, lipids, DNA. heat shock, genotoxic shock, oxidative stress, hypoxic stress
Classifications of Stress
Eustress:
-good stress
-only results in small shift in the body’s internal balance
-example: exercise or a first date
Distress:
-bad stress
-can cause major disruption in the body’s internal balance
-example: family conflict, toxic work environment
Acute/Daily stress:
-short lived
-body’s internal balance for a defined period and is minor in severity
-traffic
Major life events:
-severe magnitude
-varies in duration
-divorce, loss of a loved one
Chronic stress:
-bad stress
-recurring
-eating processed bad food
Allostatic load
-the overall burden of stress and life events
includes the following:
-daily challenges
-major life events
-poor diet
-lack of sleep
-physical activity levels
Controllable Stressors
-attitude
-outlook on life
-staying organized
-relaxation time
-avoiding food intolerances
Social Determinants of Health
conditions that have a major impact on people’s health, wellbeing, and quality of life
living location
transportation
community crime
economic status
education level
income
access to healthy food
health services
literacy
race
Response to a Stressor
-fight or flight
-production of stress hormones
-body is provided with energy
activation of the SNS
-epinephrine (adrenaline)
-norepinephrine (noradrenaline)
increase in in the following:
-blood sugar
-heart rate
-heart contractions
Activation of the HPA axis
hypothalamus:
-corticotropin releasing hormone
pituitary gland:
-adrenocorticotropic hormone
Adrenals:
-cortisol
-receptors located throughout the body
-numerous systems and functions impacted
Ex: increased blood sugar, increased blood pressure
Parasympathetic nervous system
-rest and digest
-recovery from stress
-changes seen during stress are normalized
oxytocin:
-buffers effects of stress
-“feel good” hormone
-increased physical affection
-increased desire for social interaction
-protects body from effects of stress
-anti-inflammatory
-relaxation of blood vessels
Acute stress
-short lived
examples:
-an alarm clock going off, taking an exam, acute illness, temperature change, making a phone call, exercise
-temporary activation of SNS and hPA axis
-nonessential processes and functions will be shut down
-beneficial effects like resilience and immune boosting
-hormesis: adaptive response to moderate intermittent stress such as exercise, cold plunge, sauna
Chronic stress
-prolonged activation of SNS and HPA axis
-reduced immune function
-contributes to health conditions
Suppression of bodily functions:
-digestion
-reproduction
-growth
-bone formation
Effects of chronic stress
- Elevated blood sugar and poor insulin signaling
- Increased appetite cravings and overeating
- Weight gain
- Elevated blood pressure
- Increased inflammation
- Under-functioning of the immune system
- Oxidative stress
- Hormone imbalances
- Alterations in the gut microbiome
- Poor digestion
- Changes in mental health
Chronic stress, blood glucose levels, and insulin signaling
blood sugar:
-gluconeogenesis
-increase in blood glucose levels
insulin signaling:
-muscle and liver cells can become resistant to insulins signal
-results in more sugar remaining in the blood
-can contribute to insulin resistance overtime
cortisol and insulin:
-high levels of cortisol can inhibit the signaling of insulin
-elevated cortisol is associated with increased glucose levels and decreased insulin sensitivity
Chronic stress and weight gain
Weight gain:
-increase in cravings and desire to eat
-increase in weight
Ghrelin:
-elevation in ghrelin
-primary appetite craving hormone
-direct association between cortisol and ghrelin
-ghrelin can contribute to poor insulin sensitivity and secretion