streptococcus pyogenes

Question 1

1)General feature
2)Disease and pathogenesis
3)Laboratory diagnosis

Answer 1

1)Gram+, catalase-, encapsulated, B-hemolytic, hyaluronic acid, M protein(both antiphagocytic),bacitracin sensitive
2)Pyogenic infection: pharyngitis, cellulitis, impetigo
Toxigenic- C-superantigen(erythrogenic exotoxin)scarlet fever(rash except face ,pharyngitis, strawberry face), A-superantigen-TSLS , B-protease- necrotizing fasciitis
immunopathogenic- Rheumatic fever(joint, heart and brain-basal ganglion) type 2 hypersensitivity(molecular mimicry) usually with pharyngitis, Glomerulonephritis, type 3 hypersensitivity and usually during impetigo, periorbital edema, hypertension and hematuria
SEPSIS
3)Antibody to streptolysin o