Respiratory tract viruses

Question 1

1)What can RSV cause?
2)Name origin
3)pathophysiology
4)prevention

Answer 1

1)bronchiolitis and pneumonia in infants,
otitis media(bronchitis) in child and pneumonia in elder and human with cardiopulmonary diseases
2)fusion protein(syncytial)
3)type 3 hypersensitivity(immune complex damage respiratory cells)
4)No vaccine(cause disease), IG, hand washing and gloves

Question 2

1)What can coronavirus cause?
2)Which receptor SARS use ?
3)pathophysiology of SARS

Answer 2

1)SARS and MERS pneumonia , common cold and bronchitis
2)ACE-2
3)bind to ACE-2 and block its action then AT2 is increased , water and sodium retention start and cause diffuse edema with hypoxia

Question 3

1)Why rhinovirus cause frequent and only common cold?
2)Treatment and prevention

Answer 3

1)It has 100 serotype and is not durable to stomach acid and 37 T
2)C vitamin and zinc

Question 4

1)Important properties of influenza A virus
2)what cause pandemic ?
3)pathogenesis and clinical finding
4)what can aspirin cause with viral fever?

Answer 4

1)Segmented RNA with nucleocapsid(group specific) and envelope(type specific hemagglutinin which bind to sialic acid to enter cell and antibody for host, neuraminidase cleaves mucous of respiratory tract and damage sialic acid for budding)
2)animal and human RNA reassortment within pig which change hemagglutinin antigen type
3)firstly neuraminidase damage mucosal layer and than Tc cells with IGA cause inflammation of upper and lower respiratory tract which necrotize respiratory cells, which cause upper respiratory symptoms, myalgia(cytokine release), and superinfection with S. auerus and S. pneumoniae which cause pneumonia
4)Reye syndrome which cause liver damage and such complication as encephalopathy