Corynebacterium diphtheriae

Question 1

1)General features
2)pathogenesis
3)Disease
4)prevention and treatment
5)Indigent disease

Answer 1

1)Gram+ rods with club shape
2)A-B toxin, which cause add ADP-ribose to EF-2 which inhibit protein formation and leads to cell necroses
3)local- pseudomembranous pharyngitis , bull neck(lymphadenopathy ), laryngeal or tracheal obstruction
Systemic -myocarditis(arrythmia, heart block) and neuronal damage(cranial and peripheral)
4)Vaccine and antitoxin
5)Cutaneous ulceration with rare systemic effects