strep infections Flashcards

1
Q

which bacteria have the IgA protease s a virulence factor ?

A

SHiN
strep pneumonia
Haemophilus influenza
Neisseria

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2
Q

what are the lab features of strep pyogens ?

A

group A streptococci
gram positive in chains
on;ybeta hemolytic strep that is PYR positive

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3
Q

what is the virulence factor of strep pyogens ?

A

M protein

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4
Q

what are the toxin mediated diseases in association with strep pyogens ?

A

scarlet fever
necrotizing fascitis
toxic shock syndromew

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5
Q

what are the immune diseases associated with strep pyogens ?

A

rheumatic fever
post strep GN

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6
Q

what are the 2 important skin infections in association with strep pyogens ?

A

cellulitis
impetigo

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7
Q

what are the strep pharyngitis complication ?

A

scarlet fever

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8
Q

what is the toxin associated with nscarlet fever that happens as a complication of strep pharyngitis ?

A

erythrogenic toxin
the skin reacts to this toxin

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9
Q

where is the gene for the eryhtrogenic encoded ?

A

in the lysogenic phase

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10
Q

what is distinctive about scarlet fever ?

A

strawberry tongue
sandpaper skin
can be differentiated from kawasaki by the presence of a sore throat before the appearance of the strawberry tongue

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11
Q

what toxin is associated with necrotizing fasciitis ?

A

strep pyogenic exotoxin

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12
Q

what are the two types of necrotizing fasciitis ?

A

type 1 - caused by anaerobes and usually in diabetics and in the immunocompromised
type 2 - associated with group A strep and occurs in healthy people after skin injury

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13
Q

what is the classic case associated with necrotizing fasciitis ?

A

pain that is out of proportion
can be commonly mistaken for cellulitis
may be further associated with hypotension and shock

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14
Q

what type of autoimmune reaction is rheumatic fever ?

A

type 2

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15
Q

what are the pathognomonic features of rheumatic fever ?

A

aschoff bodies - nodues in the heart , granuloma
antisckow cell- has an owl eye appearance

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16
Q

what are the lab findings associated with rheumatic fever ?

A

elevated ASO titre

17
Q

what are the clinical clues asociated with rheumatic fever ?

A

patient with a sore throat
which then presented with a new heart murmur and joint pain is most likley rheumatic

18
Q

what is the treatment for rheumatic fever ?

A

penicillin for life

19
Q

what valvular abnormality is associated with late RF ?

A

mitral stenosis

20
Q

what are the features of strep agalactai ?

A

its a group b strep which releases CAMP that interacts with beta hemolysin in staph aureus

21
Q

what is the normal flora of the vagina ?

A

group b strep 3amatan

22
Q

what is the shape of strep pneumoniae ?

A

lancet shaped gram positive cocci

23
Q

what is the most important virulence factor in strep pneumonia ?

A

IgA protease polysaccharide capsule
which is used for vaccinations

24
Q

what is the function of the polysacchride capsule in strep pneumonia ?

A

prevents phagocytosis

25
Q

what complications are associated with strep pneumonaie ?

A

MOPS
meningitis
otitis media
pneumonia
sinusitis

26
Q

which of the bstrep is part of the normal mouth flora ?

27
Q

what are the clinical applications associated with viridans ?

A

after a dental procedure may cause endocarditis disease in patients with pre existing valvular conditions

28
Q

which of the strep cause dental caries ?

A

strep mutans

29
Q

which of the strep cause subacute endocarditis ?

A

strep sanguinis

30
Q

how does viridans cause endocarditis ?

A

ferments dextran which attaches to fibrin which is found where there is endothelial damage

31
Q

what treatment is used for enterococcus ?

A

resistant to penicillin
vancomycin resistant strain
so vanco genta combination is given

32
Q

which bacteria cause nitrite negative UTI ?

A

staph saprophyticus
enterococcus

33
Q

surgical manipulation of GUT then later on presented with endocarditis , what is the most likely causative organism ?

A

enterococcus

GU manipulation like cytoscopy or TURP procedure

34
Q

which of the strep is associated with colon cancer ?

A

strep bovis