Stratified Medicine Flashcards
why are many approved drugs removed from the market
due to adverse drug effects
where is variation between people for
degree of drug response
2 problems with variability
It’s harder to predict who may benefit It’s harder to predict who may be harmed
what causes variability
Much but not all variability is caused by genetic differences
Carbamazepine-induced hypersensitivity reactions
an example of extreme variation to a drug
clinical manifestations of variability
Maculopapular exanthema= Hypersensitivity reaction
Stevens-Johnson syndrome = Toxic epidermal necrolysis
abnormal TK enzyme created by the mutation.
BCR-ABL
what is mmunomodulatory therapy
target bodies own immune defences to the tumour
Precision therapies
targeted therapies designed to interfere in specific biologic processes
3 examples of precision therapies
- Cloned proteins
- Rational molecular design of small molecules
- Immunomodulatory therapy
what are predictive factors
biomarkers for diagnosis, prognosis and therapeutic decisions
