Neuropharmacology of Dementia

Question 1

how long is beta amyloid

Answer 1

39 to 43 amino acids

Question 2

what are the two most studied forms of beta amyloid

Answer 2

Ab40 and Ab42

Question 3

which form of beta amyloid is more likely to be fibrillogenic and longer

Answer 3

Ab42

Question 4

2 classes of cognitive enhancers

Answer 4

cholinesterase inhibitors

One partial glutamate antagonist

Question 5

adverse effects of donepezil


Answer 5

nausea, vomiting, diarrhoea, muscle 
cramps, dizziness, fatigue and anorexia in the 10 mg/day group 


Question 6

Serious adverse events of donepezil


Answer 6

– Cardiac adverse events
– Peptic Ulcers/GI Bleeding 


Question 7

main drug class used in Frontotemporal dementia:

Answer 7

SSRIs because FTD has no No cholinergic deficits (

Question 8

who to treat with antipsychotics?

Answer 8

Severe agitation that is a risk to themselves or others – usually physical aggression 


Question 9

after how long of stability should antipsychotics be withdrawn

Answer 9

3 months