Stomach cells (extra bit)

Question 1

six cell types

Answer 1

1) simple columnar mucous cells
2) Mucous neck cells
3) undifferentiated stem cells
4) Parietal cells
5) Chief cells
6) enteroendocrine

Question 2

Simple columnar mucus cells

Answer 2

surface and pits. Secrete;

1) mucous coat (traps HCO3- from parietal cells= protective barrier)
2) enriched phospholipid in membrane barrier?????
3) UD stem cells: that migrate and replace surface cells

Question 3

how can the mucous coat be degraded

Answer 3

Helicobactor Pylori
1-urease of bacteria convert 
urea>ammonia which degrades mucous coat
2- toxins damage epithelium
- Ulcerogens (PAF)

Question 4

Prostoglandins

Answer 4

Protective, stimulates mucous and phospholipid production.

Especially E2

Question 5

Mucous neck cells

Answer 5

Soluble acidic alycoproteins secreted when food present

Question 6

Parietal cells

Answer 6

• HCl
  1) sterilise food
  2) acidify environment (chief cell pepsinogen > pepsin) cleaves proteins

-Intrinsic Factor (B12 absorption)

Question 7

less HCl means

Answer 7

less digestion(pepsinogen not cleaved)
less bacteria kill (gastroenteritis)

Question 8

Vitamin B12 important for

Answer 8

RBC haematopoiesis.

Low parietal cell activity > low IF > pernicious anaemia