Stimulated Excitable Cells Flashcards
Ion channels react to stimuli, increasing or decreasing ionic flux
Signal transduction
Receptor and postsynaptic potentials grow smaller with distance from initiation site
Decremental potential
Distance over which a electrical potential decays
Length constant
What does greater length constant indicate
Lesser decrement
Lower intracellular resistance
Greater membrane resistance
Which area of the axon is populated by voltage-gated sodium channels
Impulse Initiation zone
Ionic basis of action potentials
Na+ channels open then inactivate
K+ channels wait, open and inactive slowly
Inactivation ball plugs channel
Channel remains inactive until voltage resets (absolute or relative refractory)
How is the distribution of voltage-gated channels on unmyelinted axons
Sparse distribution
How is voltage-gated distribution on myelinated axons
Dense (nodes of Ranvier)
High intracellular resistance
Short length constant
Low intracellular resistance
Long length constant
Drug that blocks voltage-gated Na+ channels
Lidocaine