Paroxysms And Synaptic Plasticity Flashcards
What are memories stored as
Engrams
What are acquired pathological deficits of memory
Amnesia’s
Amnesia’s can be a result from what
Failure to produce engrams
Losses of engrams
Failure in accessing engrams
High frequency stimulation at hippocampal synapses
Long term potentiation
Low frequency stimulation at hippocampal synapses
Long term depression
High frequency stimulation
Large Ca2+ influx, receptors inserted
Low frequency stimulation
Small Ca2+ influx, receptors removed
Sudden onset bursts of neuronal activity causing seizures
Paroxysms
Pathological synchronization of neuronal activity
Seizures
Seizures lasting beyond 5 mins causing excitotoxicity (cerebral damage)
Status epilepticus
Motor is manifestations of seizure
Convulsion
Chronically heightened susceptibility to seizures
Epilepsy
Transformation of non-epileptic brain into epileptic brain
Epileptogenesus
Type of seizure that is bilateralized and consciousness throughout
Primary generalized
Type of seizure that is bilaterized and arises from a partial seizure and consciousness lost at transition from partial to generalized
Secondary generalized
Type of seizure that is localized, awareness may be preserved (simple) or disturbed (complex)
Focal (partial)
Characteristics of infantile spasms
Hypsarrhythmia
Characteristics of absence seizures
Spikes and waves
Select Antiseizure Strategies
Na+ channel blocker
Ca2+ channel blocker
GABA agonists
Two types antiseizures of drugs that are GABA agonists
Benzodiazepines
Barbiturates
Antiseizure drug that acts as a Na+ and Ca2+ channel blockers
Valproate
