Neurodevelopment Flashcards
Failure of right and left hemispheres to separate causing cleft lip/palate or cyclopia
Holoprosencephaly
Which gene is important for inducing development of eye
Pax6
Which gene forms Pro and Mes-encephalon
Emx and Otx
A rare congenital malformation of the cortex which may be absent and replaced by CSF; caused by Emx genetic defect
Schizencephaly
Hox gene expression is determined by which acid produced in the Hensen’s node
Retinoic acid
What protein is essential for layering Schwann cell membrane as myelin
Peripheral Myelin Protein-22
What does mutation in PMP-22 result in
Hypomyelination
Mutation of PMP-22 (Gly to Asp) results in which disease
Charcot Marie Tooth
Symptoms of Charcot Marie Tooth
Muscle atrophy
Clumsiness
Limb weakness
Hereditary motor and sensory neuropathy
**Onset: late childhood or in adulthood
Muscle fiber activity promotes ______ and inactivity promotes _________
Mononeural innervation
Polyneural innervation
Early development: no territories in cortex or LGN thalamus
Mid-Development: cortex not defined and LGN semi-defined
Post-natal: both are well defined
Critical Periods in Visual system
What does it mean when the stripes are equal width apart in the visual cortex
Normal ocular dominance columns
What happens to the visual cortex during monocular deprivation (sutured eye)
Changes in ocular dominance columns due to inactivity
