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Frontiers > Stem cells HSCs and MSCs > Flashcards

Stem cells HSCs and MSCs Flashcards

1
Q

In which body cells do stem cell s exist (8)

A

bone marrow, brain, skin, fat, muscle, bone, blood, intestine

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2
Q

HSCs are derived from

A

blood stem cells

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3
Q

blood stem cells split into (2)

A

myeloid stem cells and lymphoid stem cells

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4
Q

Myeloid stem cells split into (3)

A

red blood cells, platelets, myeloblast

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5
Q

lymphoid stem cell

A

lymphoblast

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6
Q

what forms white blood cells (2)

A

myeloblasts and lymphoblasts

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7
Q

where are GI stem cells located

A

crypt

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8
Q

what are GI stem cells associated with (2)

A

paneth cells and TA cells

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9
Q

Where are MSCs from

A

Bone marrow

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10
Q

MSC property

A

self renewal

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11
Q

MSCs can differentiate into what in vitro (3)

A

adipocytes, chondrocytes, osteocytes

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12
Q

adipocytes

A

fat cells

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13
Q

chondrocytes

A

cartilage cells

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14
Q

osteocytes

A

bone cells

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15
Q

cells that can become a new individual with maternal support

A

totipotent

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16
Q

cells that he can become any adult tissue cells

A

pluipotent

17
Q

cells that can become several types of mature cells

A

multipotent

18
Q

zygotes are

A

totipotent

19
Q

embryonic stem cells and iPSC are

A

pluripotent

20
Q

iPSC

A

induced pluripotent stem cells

21
Q

tissue stem cells are

A

multipotent

22
Q

pluripotent stem cells can differentiate into (2)

A

HSCs and MSCs

23
Q

HSC

A

haematopoietic stem cell

24
Q

MSC

A

mesenchymal stem cell

25
Q

MSCs can differentiate into (2)

A

fibroblasts and adipocytes

26
Q

HSCs can differentiate into (2)

A

B cells and macrophages

27
Q

what is it called when B cells differentiate into macrophages

A

transdifferentiation

28
Q

what is blood

A

fluid connective tissue

29
Q

Blood functions (7)

A

oxygen transport, nutrient transport, ormone transport, heat regulation, immune system, haemostasis, waste product removal

30
Q

haemostasis

A

clotting

31
Q

WW2

A

1939-45

32
Q

when was fear and interest in radiation therapies heightened (2)

A

post WW2 and cold war

33
Q

what treatments for cancers emerged (2)

A

radiotherapy and chemotherapy

34
Q

which elements of blood continuously renew (4)

A

granulocytes, erythrocytes, lymphocytes, platelets

35
Q

blood before centrifuge (2)

A

diluted peripheral blood and separation medium

36
Q

blood centrifuge for separation

A

2200 rpm 30 min

37
Q

blood centrifuge elements (3)

A

55% plasma, 1% platelets and PBMCs, 45% RBCs and polymorphonuclear cells

38
Q

PBMC

A

peripheral blood mononuclear cells

39
Q

plasma elements (4)

A

cytokines, water, proteins, electrolytes

Frontiers (9 decks)

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