Gut microbiome in MetSys Flashcards

1
Q

How many kg of bacteria in the body

A

0.2-1.7 kg

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2
Q

how many of strains of abcteria per person

A

500

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3
Q

how many more genes in the microbiome than our genotype

A

150

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4
Q

what is the gut microbiota (2)

A

self sustaining ecosystem, digests food

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5
Q

gut digestion process (7)

A

eat, homogenise, acidify, intestinal flora, mix, transfer, poo

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6
Q

when is gut microbiome at its largest

A

adult

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7
Q

when is gut microbiome smallest

A

in utero

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8
Q

what affects gut microbiome in utero

A

maternal transfer

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9
Q

what affects gut microbiome toddler (3)

A

delivery, feeding, maternal health

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10
Q

what affects gut microbiome adult (10)

A

diet, genetics, sex hormones, antibiotics, PPIs, probiotics, hygeine, GI disease, food additives, xenobiotics

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11
Q

what affects gut microbiome old age (3)

A

immune decline, diet diversity, inflammation

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12
Q

how much fibre pre industrial diet

A

50-100 g/day

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13
Q

Australian recommended fibre/day

A

25-38 g/day

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14
Q

average intake fibre/day Australia

A

16 g/day

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15
Q

how has diet changed from pre industrial (6)

A

high fat, high sugar, high salt, highly refined, highly processed, low in fibre

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16
Q

MAC

A

microbial accessible carbohydrate

17
Q

MAC types (3)

A

non starch polysaccharides, resistant starch, soluble oligo/polysaccharides

18
Q

how fermentable are non starch polysaccharides

A

20-90%

19
Q

non starch polysaccharides (2)

A

cellulose and hemicellulose

20
Q

hemicellulose types (4)

A

pectin, beta glucans, xyloglucans, arabiongalactans

21
Q

resistant starch fermentability

A

100%

22
Q

resistant starches

A

R1-4

23
Q

soluble oligo/polysaccharide fermentability

A

100%

24
Q

soluble oligo/polysaccharides (2)

A

inulin and FODMAPs

25
Q

FODMAPs (4)

A

fermentable oligo, di, monosaccharides, polyols