Stem Cells

Question 1

What stem cells can be ?

Answer 1

The stem cells can be adult tissue-renewingstem cells, which may be described as oligopotent or pluripotent (giving rise to fewer [oligo] or more [pluri] different cell types in the tissue of interest)

Question 2

What are stem cells ?

Answer 2

an undifferentiated cell of a multicellular organism which is capable of giving rise to indefinitely more cells of the same type, and from which certain other kinds of cell arise by differentiation.

• Can regenerate tissue and self-renew
• Infrequent, asymmetric cell division

Question 3

What are the Transit Amplifying cell ?

Answer 3

• Committed to differentiation
• No self-renewal
• Rapid cell divisions to increase “bulk”

Question 4

Terminally differentiated cells

Answer 4

• Serve specialised tissue functions

* Do not divide or regenerate

Question 5

Quality control of the cell cycle is exerted by inhibiting cyclin/Cdkcomplexes

Answer 5

DNA damage : G1/S-CDK /S-cDK(

Unreplicated DNA and DNA damage M-CDK-

Chromosome unattached to spindle APC/C

Question 6

Does Tissue renewal depend on stem cell ?

Answer 6

Tissue renewal does not depend on stem cells: Insulin-producing bcells in islets of Langerhans renew themselves

Question 7

Does an organ require stem cells to regenerate?

Answer 7

No, liver can be regenerated from hepatocytes.