SS Tracts: Tactile, Discrimination, and Position Sense (Dennis) Flashcards
What is the function of the somatosensory system and the associated pathways?
- function: transmits and analyzes touch or tactile info from external and internal locations on the body and head (i.e. discriminative touch, flutter-vibration, proprioception, crude touch, thermal sensation, nociception)
- pathways: posterior column medial lemniscal pathway, trigeminothalamic pathway, spinocerebellar pathway, anterolateral system
- ascending tract involved w/ perception of mechanical stimuli
- discriminative touch (two-point discrimination); pressure, stretch, and vibrations of skin; and proprioception
- has fast conduction velocities and precise somatotopic organization
posterior column-medial lemniscal system (PCMLS)
- area of skin innervated by somatic afferent fibers
- small fields have high receptor density while larger fields have lower receptor density
receptive field
What are the 1st order neurons within the PCMLS, where are they located, and what are their attributes?
- primary afferent fibers that are sensory axons located within the DRG
- large-diameter fibers that relay discriminative touch, flutter-vibration, and proprioception
- enter the SC via medial division of the posterior root (gray horn) and then branch
- largest set of branches ascend cranially and form posterior columns (white matter): fasiculus gracilis (below T6) and fasiculus cuneatus (above T6)
- some branches terminate on 2nd order neurons in, at, above, and below level of entry (reflexes)
What is the organization of FG and FC?
fibers are organized topographically, sacral fibers are medial and fibers from progressive rostral levels are added laterally
What would a lesion in the FG or FC area of the SC result in?
(fibers in FG and FC run ipsilateral, meaning they do not crossover)
- lesions would result in *ipsilateral reduction or loss of discriminative, positional, vibratory, tactile sensations at and below the segmental level of injury*
- sensory ataxia: loss of muscle stretch (tendon) reflexes, and proprioceptive losses from extremities due to lack of sensory input
- also possible is a wide-based stance and placing of feet to the floor w/ force, in effort to create missing proprioceptive input
Where are the 2nd order neurons located in the PCMLS and what is their function?
- 2nd order neurons are located in the nucleus gracilis and nucleus cuneatus in the posterior medulla
- receive input from 1st order neurons (primary afferents) from ipsilateral DRG
- each nucleus receives inputs from its corresponding fasciculus, maintaining somatotopic organization of projections
Where are the 3rd order neurons located in the PCMLS and how are these fibers projected elsewhere?
- ipsilateral NC and NG combine and loop contralaterally in the posterior medulla posterior to the pyramids, creating the internal arcuate fibers
- these fibers cross the midline (sensory decussation) and ascend as the nerve bundles of right and left medial lemniscus (ML)
- ML terminates in the ventral posterolateral nucleus (VPL) in the thalamus, where the 3rd order neurons are housed that are projected into the cortex
How does the ML fibers rotate through the brainsteam and what is its orientation throughout the rotation?
- in the medulla, the ML is oriented w/ as if the fibers are “standing up” on the pyramids w/ the UE fibers posterior and LE fibers anterior
- in rostral medulla and caudal pons, the ML flattens horizontally so that the UE fibers lie medially and LE fibers lie laterally
- in the midbrain, the ML turns vertically and shifts laterally so that the UE fibers lie anterior and LE fibers lie posterior
*somatotopic orientation shifts as the fiber tract rotates*
(figure image captions are incorrect)
What is the role of VPL in the PCMLS?
- the ventral posterolateral (VPL) nuclei are located in the caudal thalamus and contain 3rd order neurons of the PCMLS
- somatotopic organization maintained in VPL
- these neurons traverse posterior limb (1/3) of internal capsule, eventually moving in the primary (SI) and secondary (SII) somatosensory cortices
What would a lesion in the VPL or IC portion of the PCMLS result in?
- these regions are supplied by thalamogeniculate branches of posterior cerebral artery
- lesion or infarction could result in loss of all tactile sensation over the contralateral body (VPL) and head/face (VPM)
Where do fibers travel after the internal capulse in the PCMLS?
- fibers move to corona radiata and then the primary (SI) and secondary (II) somatosensory cortices
- primary (SI) cortex: comprises postcentral gyrus and posterior paracentral gyrus (bordered by central sulcus anteriorly and postcentral sulcus posteriorly); subdivided anterior to posterior into Brodmann areas 3a, 3b, 1, and 2
- secondary (SII) cortex: located in the inner face of the upper bank of lateral sulcus and lateral to SI, receives inputs from ipsilateral SI cortex and ventral posterior inferior nucleus (VPI) of the thalamus
- parietal cortical regions also receive tactile inputs apart of the PCMLS
What would a lesion in the primary SS cortex result in?
primary (SI) cortex lesion
- blood supply to SI cortical areas is provided by anterior and middle cerebral arteries
- MCA lesions produce tactile loss over contralateral upper body and face
- ACA lesions affect the contralateral lower limb
What would a lesion in the parietal cortical region result in?
parietal cortical region lesion
- lesions in this area can produce agnosia
- contralateral body regions lost from body map
- limb is not recognized as part of the patient’s own body
- sensation is not radically altered
- “foot to tongue” pattern along medial to lateral axis of SI and SII
- regions w/ increased receptor density (hands/lips), have large amount of dedicated cortical tissue
- regions w/ decreased receptor density (back) have small cortical representations
somatosensory homunculus