Physiology of Auditory and Vestibular Systems Flashcards
detects sounds and uses acoustic cues to identify and locate sound sources in the environment
auditory system
oscillations of air pressure that vary rapidly w/ time
sound
sound pressure (intensity) specified by a scale of sound pressure level in decibels (dB)
amplitude
number of oscillations of air pressure per second (Hz)
frequency
How does displacement of hair cells along the basilar membrane contribute to differences in sound frequency?
- the motion is a traveling wave from base of cochlea to apex where the wave patterns differ for different frequencies
- the basilar membrane varies in structure over its length
- the membrane near the base and oval/round windows is narrow/stiff and experiences maximal motion for high frequencies
- the membrane near the apex and helicotrema is wider/more flexible and experiences maximal motion for lower frequencies
sounds that cause greater deflection of the basilar membrane near the base where it is narrow/stiff
high frequency sounds
sounds that cause greater deflection of the basilar membrane near the helicotrema where it is loose/flexible
lower frequency sounds
- frequency of sound
- coded by where along the basilar membrane there is the greatest deflection
pitch
- polarized epithelial cells w/ basal and apical ends
- contain stereocilia on apical surface and neural synapses on basal side
- stiff, graded in size, and rich in actin
- cell type that receives afferent and efferent input, however they are not neuronal
- these cells are mechanoreceptors: convert mechanical signals to electrical signals
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hair cells
- potassium-RICH fluid filling cochlear duct and membranous labyrinth
- bathes apical end of hair cells
- similar to ICF: high in K+, low in Na+
- found in scala media
- produced by stria vascularis
endolymph
- potassium-POOR fluid that bathes basal end of cochlear hair cells
- similar to ECF: high Na+, low K+
- found in scala vestibuli and scala tympani
perilymph
What are the differences between endolymph and perilymph at what do these differences contribute to?
- endolymph is high in K+ and found in scala media
- perilymph is low in K+ and found in scala vestibuli and scala tympani
- these differences in ion conc and location of fluid leads to a charge differential that readily allows K+ to flow into hair cells once the stereocilia have been deflected
How is an action potential generated by a hair cell?
- following deflection of stereocilia toward longest stereocilia, K+ ions enter cell and depolarize it
- stereocilia are connected to each other via tip links that transmit force to elastic gating spring (protein bridge), allowing the stereocilia to bend together and, in turn, open the cation gates (even small vibrations of 0.3 nm can cause channel opening)
- depolarization occurs when mechanically gated K+ cation channels open at apex of stereocilia and allow influx of K+
- depolarization causes the voltage-gated channels (TRPA1) to open, allowing Ca2+ to flow into the cell
- Ca2+ influx allows for further depolarization, causing the hair cell to release NT glutamate (excitatory) which generates an action potential in CN VIII
(at rest, hair cell is partially depolarized, however this is not enough to trigger an AP)
What does the directional deflection of stereocilia lead to?
(stereocilia linked together, thus they deflect as a bundle)
- deflection toward tallest stereocilia: depolarization
- deflection in opposite direction: hyperpolarization
How does the stria vascularis maintain electrochemical properties of the endolymph and contribute to sound conduction?
- located in lateral wall of cochlear duct (scala media) and produces endolymph w/ high K+ conc
- this creates high endocochlear potential (+80 mV) that drives positively charged ions into hair cell down their concentration gradient, thereby contributing to generation of AP
- this also forms the blood-labyrinth barrier (BLB)
What is the relationship between blood-labyrinth barrier, stria vascularis, and hearing loss?
- stria vascularis (SV) establishes the blood-labyrinth barrier (BLB) by prod endolymph which creates high endocochlear potential
- BLB is main site of drug entry to access inner hair cell, sometimes to its detriment
- any substance (meds, drugs, CO, etc) that disrupt SV function or damages SV will diminish endocochlear potential and impact hearing
- stria vascularis is a common source of ototoxic drug secretion into cochlea (crosses BLB)