Development of the Brain (Dennis) Flashcards
- cells that differentiate and proliferate, eventially migrating into the intermediate zone and marginal zone
neuroepithelial cells
- superficial to the marginal zone is sclerotomal mesenchyme that will become the _________
- in the SC, the neural canal will become the _____ ______, and is lined by _______ _____ derived from neural tube
- superficial to the marginal zone is sclerotomal mesenchyme that will become the meninges
- in the SC, the neural canal will become the central canal, and is lined by ependymal cells derived from neural tube
this dividing line separates neuroepithelial cells that take on different roles depending on the division
sulcus limitans
Describe the general process of neurulation:
- notochord forms from mesoderm cells soon after gastrulation is complete
- signals from notochord cause inward folding of ectoderm at neural plate
- ends of neural plate fuse and disconnect to form an autonomous neural tube
(tube is developed outward in the directions of the cranial and caudal neuropores)
When does the brain start forming and where is it located in the developing embryo?
- develops during 3rd week from neural tube
- located cranial (superior) to 4th pair of somites
What are the 3 primary vesicles and how are they formed?
- prosencephalon (forebrain)
- mesencephalon (midbrain)
- rhombencephalon (hindbrain)
- form from fusion of neural folds in cranial region and closure of rostral neuropore
What are the 5 secondary vesicles and what do they form from?
(form during 5th week)
- prosencephalon (forebrain) divides and creates telencephalon and diencephalon
- mesencephalon remains the midbrain
- rhombencephalon (hindbrain) divides and creates metencephalon and myelencephalon
What are the adult derivatives of the telencephalon?
- walls: cerebral hemispheres
- cavities: lateral ventricles
What are the adult derivatives of the diencephalon?
- walls: thalamus, hypothalamus, epithalamus
- cavities: third ventricle
What are the adult derivatives of the mesencephalon?
- walls: midbrain
- cavities: aqueduct
What are the adult derivatives of the metencephalon?
- walls: pons and cerebellum
- cavities: upper part of fourth ventricle
What are the adult derivatives of the myelencephalon?
- walls: medulla
- cavities: lower part of fourth ventricle
What are the 3 brain flexures and how do they form?
- developing space for neural tube is limited, but there is extensive growth which causes neural tube to bend or flex which creates the flexures; they form w/ the primary vesicles and then into the secondary vesicles (5th week)
- the two ventral flexures are midbrain flexure and cervical flexure, while the dorsal flexure is the pontine flexure
- flexure that demarcates hindbrain from SC
- arbitrarily defined at superior rootlet of C1, roughly at foramen magnum
cervical flexure
- flexure that demarcates metencephalon (rostral) from myelencephalon (caudal)
pontine flexure