SPMM

Question 1

Antidepressant which can prolong QTc in normal doses

Answer 1

Trazodone

Question 2

Antidepressant which can cause dependence

Answer 2

Tranylcypromine

Question 3

Clozapine induced neutropaenia risk factor

Answer 3

Young age

NOT dose dependent

Question 4

Rivastigmine

Answer 4

No hepatic metabolism

Question 5

Social phobia tx

Answer 5

MAOIs superior to other antidepressants (especially phenelizine)

Question 6

Lamotrigine

Answer 6

Valproate increases levels
Can increase likelihood of rash

Question 7

Renal clearance of lithium

Answer 7

Theophylline increases

NSAIDs, thiazides, furosemide - decrease

Question 8

Zopiclone SE

Answer 8

Metallic taste

Question 9

Serotonin breakdown

Answer 9

MAO-A

Question 10

SSRI

Answer 10

Do not cause hypertension

Can cause akathisia, galactorrhea, photosensitivity

Question 11

Serotonin autoreceptors

Answer 11

5-HT1B

Question 12

Highly selective dopamine antagonistic

Answer 12

Sulpride, amisulpride

Question 13

Amitriptyline to citalopram

Answer 13

Half dose, start new drug, then slow withdrawal

Question 14

Clozapine: RF for agranulocytosis

Answer 14

Female sex
Older age
Asian or Ashkenazi jewish

Question 14

Clozapine: RF for neutropaenia

Answer 14

Younger age
Afro-Caribbean
Low baseline WCC

Question 15

Caridopa MOA

Answer 15

Inhibits dopa decarboxylase

Question 16

GHB

Answer 16

GABA-B

Question 17

Z drug half lives

Answer 17

Zopiclone 5 hours
Zolpidem 2.4 hours
Zaleplon 1 hour

Question 18

SSRI half lives

Answer 18

Fluvoxamine 17-22 hr
Sertraline 22-36 hr
Paroxetine 24 hr
Escitalopram 30 hr
Fluoxetine 4-6 days

Question 19

Renal impairment

Answer 19

Amisulpride and sulpride almost totally renally excreted

Question 20

Antipsychotic to use in hyponatraemia

Answer 20

Clozapine

Question 21

Pure D2 antagonist