ADHD meds

Question 1

Dexamphetamine / lisdexamphetamine (prodrug)

Answer 1

STIMULANT

Increase synaptic levels of DA and NA

Decreased appetite, weight loss, insomnia, nervousness

CI - CV disorders, MAOIs, glaucoma, porphyria, psychosis, BPAD, anorexia, suicidal ideation, hyperthyroid, pregnancy and lactation, tourettes

Question 2

Methylphenidate

Answer 2

STIMULANT

Increase synaptic levels of DA and NA

Decreased appetite, insomnia, nervousness, headache, dry mouth, nausea

CI - CV disorders, MAOIs, glaucoma, porphyria, psychosis, BPAD, anorexia, suicidal ideation, hyperthyroid, phaeochromocytoma

Question 3

Atomoxetine

Answer 3

NON STIMULANT

Increase NA levels in synaptic cleft (targets NET)

Reduced appetite, N&V, abdo pain, headache, somnolence, increased BP and HR

CI - MAOIs, glaucoma, phaeochromocytoma, CV disorders

Question 4

Guanfacine

Answer 4

NON STIMULANT

Selective agonist of alpha 2A receptors, binds to postsynaptic alpha 2A receptors mimicking NA

Somolence (40%), headache (27%), fatigue (18%), abdo pain (12%)

No specific CI other than allergy

Question 5

Clonidine

Answer 5

NON STIMULANT

Agonist of alpha 2 receptors

Dizziness, sedation, orthostatic hypotension, dry mouth

CI- severe bradycardia from sick sinus syndrome / 2nd / 3rd degree AV block

Question 6

Amfetamine

Answer 6

STIMULANT

Increase synaptic DA and NA levels by blocking reuptake (via DAT and NAT), promotes release from presynaptic cleft, disrupts function of VMAT, blocks SERT

Question 7

Methylphenidate 22% IR, 78% LA

Answer 7

Affenid XL
Concerta XL
Delmosart XL
Matoride XL
Xaggitin XL
Xenidate XL

Question 8

Methylphenidate 30% IR, 70% LA

Answer 8

Equasym XL

Question 9

Methylphenidate 50% IR, 50% LA

Answer 9

Medikinet XL
Metyrol