Antipsychotic MOA

Question 1

Amisulpride

Answer 1

D2/D3 selective antagonist (low affinity selective antagonist for D2 like receptors (D2=D3>D4), it has little affinity for D1 like receptors and non dopaminergic receptors

Question 2

Olanzapine

Answer 2

Dopamine and 5HT2 antagonism

Question 3

Aripiprazole

Answer 3

Partial agonist at 5HT1A and D2, 5HT2A antagonist

Question 4

Clozapine

Answer 4

Dopamine and serotonin antagonist (5HT2A)
High affinity for D4 = less EPSEs
5HT1A partial agonist = reduced negative symptoms
M1, M2, M3, M5, histamine, alpha-1 adrenergic-receptor antagonist
Norclozapine (metabolite) actively works on M1 and M4 receptors

Question 5

Lurasidone

Answer 5

Dopamine D2, 5HT2A, 5HT7, alpha2A and alpha2c - adrenoceptor antagonists, partial agonist at 5HT1a

Does not bind to histaminergic or muscarinic receptors

Question 6

Cariprazine

Answer 6

D3/D2 partial agonist, 5HT1A partial agonist, 5HT2B and 5HT2A antagonism

Question 7

Raclopride

Answer 7

D2/D3 antagonise (used in PET scans not therapeutically)