Antipsychotics Flashcards
1st gen
‘Typicals’
Neurological SEs
Mostly DA
2nd gen
‘Atypicals’
Metabolic SEs
DA + SE
EPSEs
Acute dystonia - hours (give antocholinergic e.g. IV benadryl)
Akathesia - days
Akinesia - weeks
Tardive dyskinesia - 3-5% chance of development for every year of 1st gen antipsychotic use
NMS
Treat with DANtrolene or bromocriptine
Typicals
Chlorpromazine - first discovered. - DA, - ACh, - NE, - His leading to wide range of SE. CHLORneal deposits
Thioridazine - reTinal deposits
Haloperidol - more selective for D2 blocking, higher risk of EPSE
Atypicals
Clozapine - agranulocytosis (1% during first year)
Olanzapine - weight gain
Risperidone - less sedating (Rise and shine), high prolactin (Rise pair)
Quetiapine - sedating (Quiet time)
Ziprasidone - QTc prolongation
Aripiprazole (DA, SE) - more helpful for maintenance,
High risk of weight gain
Olanzapine
Clozapine
Low risk of weight gain
Amisulpride
Aripiprazole
Asenapine
Brexipiprazole
Cariprazine
Haloperidol
Lumateperone
Lurasidone
Sulpride
Trifluoperazine
Ziprasidone
No effect on QTc
Brexipiprazole
Cariprazine
Lurasidone
Lumateperone
Low effect on QTc
Aripiprazole
Asenapine
Clozapine
Flupentixol
Fluphenazine
Perphenazine
Prochlorperazine
Olanzapine
Paliperidone
Risperidone
Sulpride
High effect on QTc
Any IV antipsychotic
Pimozide
Sertindole
Any drug or combination of drugs exceeding recommended maximum
Associated with postural hypotension
Risperidone
Clozapine
Olanzapine
Paliperidone
Quetiapine
Zipradisone
Antipsychotics to try if postural hypotension is a problem
Amisulpride
Aripiprazole
Haloperidol
Sulpride
Trifluoperazine
Half-life
Aripiprazole - 75 hours
Olanzapine - 30 hours
Risperidone - 20 hours
Clozapine - 12 hours
Amisulpride - 12 hours
Ziprasidone - 7 hours
Quetiapine - 6 hours
