Spina Bifida Flashcards
What is myelodysplasia?
An abnormality in development of the spinal cord
what is anencephaly?
Lack of closure in region of head
What is spina bifida?
Lack of closure below the head
(true/false) Most infants with anencephaly live after birth
false (die within a few days of birth)
definition: Congenital malformation of spinal cord
neural tube defect
(true/false) spina bifida differs by racial/ethnic group
true –> more prevalent in hispanics
The prevalence of spina bifida has (decreased/increased)
decreased
What is spina bifida aperta?
spina bifida with visible or open lesions
What is spina bifida occulta?
Spina bifida with hidden lesions
What is a Myelomeningocele?
A form of spina bifida aperta that is characterized by a Sac containing the spina cord that protrudes dorsally and is not covered by skin.
What form of spina bifida aperta is associated with spinal nerve paralysis?
Myelomeningocele
What is meningocele?
A form of spina bifida aperta that is characterized by a sac with few to no nerves and is covered by skin.
What form of spina bifida aperta does not have paralysis?
meningocele
What is found in the sac when meningocele is present?
membranes and CSF –> minimal/no nerves
(true/false) Spina bifida occulta has fusion of the vertebral arch.
FALSE
(true/false) Spina bifida occulta has no tissue disturbance
true
What is spina bifida occulta normally associated with?
mild urinary tract disorders
Where is spina bifida occulta commonly found?
lumbosacral region
What characteristic of spina bifida occulta is indicative of suspicion for it?
tuft of hair or dimple present
What is a lipoma?
A visible form of spina bifida occulta that is a subcutaneous fat mass that varies in size.
(true/false) Lipoma may/may not involve paralysis
true
definition: Band separates spinal cord into hemicords
Diastematomyelia
–> Cord tethering may result in progressive weakness
(true/false) Diastematomyelia may be associated with paralysis
true
What is a Myelocystocele?
Cysts of the spinal cord that occurs in the lumbosacral region and is skin covered.
–> may or may not be associated with nerve impairment
definition: Neural tube fails to close between 3rd and 4th weeks gestation
Abnormal neurulation
definition: Cells distal to S2 typically adhere together to form canals which attach to the spinal cord, this process occurs abnormally
Abnormal canalization
Who has a higher risk of having a baby with NTDs? Why?
a. Significantly higher risk in women who did not graduate from high school and lived in low-SES neighborhoods
b. Women in higher social groups are more likely to use folic acid
NTDs are common in mothers < ___ y/o and > ___y/o
< 19
> 40
(true/false) There is an increased risk of NTDs with increased total caffeine consumption during the year before pregnancy
true
Antibacterial medication (preconceptional and first trimester) and use of SSRI’s increased risk of ______.
anencephaly