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STEP1 > SPET1_FC_Pharmacology > Flashcards

SPET1_FC_Pharmacology Flashcards

1
Q

Epinephrine

A

alpha 1,2; beta 1,2

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2
Q

NE

A

alpha 1,2; beta 1

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3
Q

Isoproterenol

A

beta 1,2

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4
Q

Dopamine

A

alpha 1,2; beta 1,2

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5
Q

Dobutamine

A

alpha 1,2;beta 1*, 2

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6
Q

Phenylephrine

A

alpha 1,2

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7
Q

Albuterol, salmeterol, terbutaline

A

beta 1,2

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8
Q

Ritodrine

A

beta 2

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9
Q

Epinephrine

A

anaphylaxis, glaucoma (open angle), asthma, hypotension

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10
Q

NE

A

Hypotention (decreased renal profusion)

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11
Q

Isoproterenol

A

Torsade de points, bradyarrhythmias (can worsen ischemia)

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12
Q

Dopamine

A

Shock (renal profusion), HF, inotropic and chronotropic

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13
Q

Dobutamine

A

HF, cardic stress testing; inotropic and chronotropic

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14
Q

Phenylephrine

A

hypotention (vasoconstrictor), ocular procedure (mydriatic), rhinitis (decongestant)

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15
Q

Albuterol, salmeterol, terbutaline

A

acute asthma (metaproterenol and albuterol); long-term asthma or COPD (salmeterol); reduce premature uterine contrations (terbutoline)

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16
Q

Ritodrine

A

reduce premature uterine contrations

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17
Q

acetaminophen

A

N-actylcysteine (replinish gluthione)

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18
Q

Salicylates

A

NaHCO3 (alkalinize urine)

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19
Q

Amphetamines (basic)

A

NH4CL (acidify urine)

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20
Q

Actelcholinesterase inhibitors, organophosphates

A

atropine, pralidoxime

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21
Q

Antimuscarinic, anticholinergic agents

A

physostigmine salicylate, control hyperthermia

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22
Q

beta blockers

A

glucagon

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23
Q

digitalis

A

normalize K, Liocaine, Anti-dig Fab, Mg2+

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24
Q

Iron

A

DeFEroaxamine, deFErasirox

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25
Q

Lead

A

CaEDTA, dimercprol, succimer

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26
Q

Mercury, arsenic, gold

A

Dimercaprol (BAL), succimer

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27
Q

Copper, arsenic, gold

A

Penicillamine

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28
Q

Cyanide

A

Nitrite + thiosulfate, hyroxocobalamin

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29
Q

Methemoglobin

A

Methylene blue, vitamin C

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30
Q

CO

A

100% O2, hyperbaric O2

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31
Q

Methanol, ethlylene glycol (antifreeze)

A

Fomepizle> ethanol, dialysis

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32
Q

Opioids

A

Naloxone/naltrexone

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33
Q

Benzodiazepines

A

Flumazinil

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34
Q

TCAs

A

NaHCO3 (plasma alkalinization)

35
Q

Heparin

36
Q

Warfarin

A

Vitamin K, FFP

37
Q

tPA, streptokinase, urokinase

A

Aminocaproic acid

38
Q

Theophylline

A

beta blocker

39
Q

Caronary Vasospasm [cause]

A

cocaine, sumatriptan, ergot alkaloids

40
Q

Cutaneous Flushing [cause]

A

vancomycin, adenosine, niacin, Ca2+ channel blockers

41
Q

Dilated Cardiomyopathy [cause]

A

Doxorubicin (adriamycin), daunorubicin

42
Q

Torsades de pointes [cause]

A

Class III (sotalol) and Class IA (quinidine) antiarrhthmics

43
Q

Agranulocytosis [cause]

A

clozapine, carbamazepine, colchicine, prophylthiouricil, methimazole, daspone

44
Q

Aplastic anemia [cause]

A

chloramphinenicol, benzene, NSAIDs, propylthiouracil, Methimazole

45
Q

Direct Coombs-positive hemolytic anemia [cause]

A

Methyldopa, penicillin

46
Q

Grey baby syndrome [cause]

A

chloramphenicol

47
Q

Hemolysis in G6PD-deficient patients [cause]

A

Isoniazid (INH), sulfanamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

48
Q

Megaloblastic anemia [cause]

A

Phenytoin, Methotrexate, Sulfa drugs

49
Q

Thrombotic complications [cause]

50
Q

Cough [cause]

51
Q

Pulmonary Fibrosis [cause]

A

Bleomycin, amiodarone, busulfan

52
Q

Acute, cholestatic hepatits, jaundice [cause]

A

Erythromycin

53
Q

Focal to massive hepatic necrosis [cause]

A

Halothane, Amanita phalloides, Valproic acid, Acetaminophen

54
Q

Hepatitis [cause]

55
Q

Pseudomembranous colitis [cause]

A

Clindamycin, ampicillin

56
Q

Adrenal insufficiency [cause]

A

GC withdrawel (HPA suppression)

57
Q

Gynecomastia [cause]

A

Spirinolactone, digitalis, cimitidine, chronic alcholol use, estrogens, ketoconazole

58
Q

Hat flashes [cause]

A

tamoxifen, clomiphene

59
Q

Hyperglycemia [cause]

A

niacin, tacrolimus, protease inhibitors, HCTZ, corticosteroids

60
Q

Hypothyroidism [cause]

A

Lithium, amiodarone, sulfonamides

61
Q

Fat redistribution [cause]

62
Q

Gingival hyperplasia [cause]

A

Phenytoin, verapamil

63
Q

Gout [cause]

A

Furosemide, thiazides, niacin, chyclosporine

64
Q

Myopathies [cause]

A

Fibrates, niacin, colchine, hydroxychloroquine, Interferon-alpha, penicillamine, statin, GC

65
Q

Osteoporosis [cause]

A

Corticosteroid, heparin

66
Q

Photosensitivity [cause]

A

Sulfonamides, amiodarone, tetracyclin

67
Q

Rash (SJS) [cause]

A

Penicillin, ethosux, carbamazepine, sulfa drugs, lamotrigine, allopurinol, phenytoin, phenobarbital

68
Q

SLE-like sydrome [cause]

A

hydralazine, isoniazid, procaainamide, phenytoin

69
Q

Teeth (kids) [cause]

A

tetracyclines

70
Q

Tedonitis, tendon rupture, and cartilage damage [cause]

A

Fluoroquinolones

71
Q

DI [cause]

A

Lithium, demeclocycline

72
Q

Fanconi’s syndrome [cause]

A

EXPIRED tetracycline

73
Q

Hemorrhagic cystisi [cause]

A

cyclophosphamide, ifosfamide (prevent by coadministering with mensa)

74
Q

Interstitial nephritis [cause]

A

Methicillin, NSAIDs, furosemide

75
Q

SIADH [cause]

A

Carbamazipine

76
Q

Cinhoncism [cause]

A

Quinidine, quinine

77
Q

Parkinson-like syndrome [cause]

A

Antipsychotics, reserpine, metoclopramide

78
Q

Seizures [cause]

A

Isoniazid, Bupropion, Imipenem/cilastatin, tramadol, Enflurane, Metoclopramide

79
Q

Tardive dyskenisia [cause]

A

Antisychotics

80
Q

Antimuscarinic [cause]

A

Atropine, TCAs, H-blockers, neuroleptics

81
Q

Disulfiram-like rxn [cause]

A

Metronidazole, certain cephalosporins, procabazine, 1st generation sulfonylureas

82
Q

Nephrotoxicity/ototoxicity [cause]

A

Aminoglycosides, vancomycin, loop diuretics, cisplatin

83
Q

P 450 (+) Inducers

A

Modafinil, Barbituates, St. John’s Wart, Phenytoin, Rifampin, Griseofulvin, Carbamazepine, Chronic alcohol use

84
Q

P 450 (-)

A

macrolids, Amiodarone, Grapefruit juice, Isoniazid, Cimetidine, Ritonavir, Acute alcohol abuse, cirpofloxacin, ketoconazole, sulfonamides, gemfibrozil, quinidine

STEP1 (13 decks)

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