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STEP1 > SPET1_FC_Diseases_assoc_neoplasm > Flashcards

SPET1_FC_Diseases_assoc_neoplasm Flashcards

1
Q

Down syndome

A

ALL; AML

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2
Q

Xeroderma pigmentosum, albinism

A

Melanoma, basal cell carcinoma, SCC of skin

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3
Q

Chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants

A

Gastric adenocarcinoma

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4
Q

Tuberous sclerosis (facial angiofibroma, seizures, mental retardation)

A

Giant cell astrocytoma, renal anfiomyolipoma, and cardiac rhabdomyoma

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5
Q

Actinic Keratosis

A

SCC of skin

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6
Q

Barret’s esophagus (chronic GI reflux)

A

Esophageal adenocarcinoma

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7
Q

Plummer-Vinson synrome (decrease iron)

A

SCC of esophagus

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8
Q

Cirrhosis (ETOH, HepB, HepC)

A

Heptaocellular carcinoma

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9
Q

UC

A

Colonic adenocarcinoma

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10
Q

Paget’s disease of bone

A

2” osteosarcoma and fibrosarcoma

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11
Q

Immunodeficiency states

A

Maligant lymphomas

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12
Q

AIDS

A

Aggressive malignant lymphomas (non-H) and Kaposi’s sarcoma

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13
Q

Autoimmune disease (Hashimoto’s thyroiditis, myasthenia gravis)

A

Lymphoma

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14
Q

Acanthosis nigricans (hyperpigmentation and epidermal thickening)

A

Visceral malignancy (stomach, lung, uterus)

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15
Q

Dysplastic nevus

A

Malignant melanoma

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16
Q

Radiation exposure

A

Leukemia, sarcoma, papillary thyroid cancer, breast cancer

17
Q

Associated Tumor

A

Gene Product

18
Q

abl [GoF]

A

CML /// Tyrosine Kinase

19
Q

c-myc [GoF]

A

Burkitt’s lymphoma /// Transcription factor

20
Q

bcl-2 [GoF]

A

Follicular and undifferentiated lymphomas (inhibits apoptosis) /// Anti-apoptotic molecule

21
Q

HER2/neu (c-erbB2) [GoF]

A

Breast, ovarian, gastric carcinoma /// Tyrosine kinase

22
Q

ras [GoF]

A

Colon carcinoma /// GTPase

23
Q

L-myc [GoF]

A

Lung tumor /// Transcription factor

24
Q

M-myc [GoF]

A

Neuroblastoma /// Transcription factor

25
Q

ret [GoF]

A

MEN 2A and 2B /// Tyrosine kinase

26
Q

c-kit [GoF]

A

Gastrointestinal stromal tumor (GIST) /// Cytokine receptor

27
Q

Rb

A

Retinoblastoma, osteosarcoma /// Inhibits E2F; blocks G1 –> S phase

28
Q

p53

A

Most human cancers, Li-fraumeni syndrome /// Transcription factor for p21, blocks GI —> S phase

29
Q

BRCA1

A

Breast cancer and ovarian cancer /// DNA repair protein

30
Q

BRCA2

A

Breast cancer and ovarian cancer /// DNA repair protein

31
Q

p16

A

Melanoma

32
Q

BRAF

A

Melanoma /// B-raf

33
Q

APC

A

Colorectal cancer (associared with FAP)

34
Q

WT1

A

Wilms’ Tumor (nephoblastoma)

35
Q

NF1

A

NeuroFibromatosis type 1 /// RAS GTPase activating protein (RAS-GAP)

36
Q

NF2

A

NeuroFibromatosis typer 2 /// Merlin (schwannomin) protein

37
Q

DPC4

A

Pancreatic cancer /// DPC - deleted in pancreatic cancer

38
Q

DCC

A

Colon cancer /// Deleted in colon cancer

STEP1 (13 decks)

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