SPET1_FC_Diseases_assoc_neoplasm

Question 1

Down syndome

Answer 1

ALL; AML

Question 2

Xeroderma pigmentosum, albinism

Answer 2

Melanoma, basal cell carcinoma, SCC of skin

Question 3

Chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants

Answer 3

Gastric adenocarcinoma

Question 4

Tuberous sclerosis (facial angiofibroma, seizures, mental retardation)

Answer 4

Giant cell astrocytoma, renal anfiomyolipoma, and cardiac rhabdomyoma

Question 5

Actinic Keratosis

Answer 5

SCC of skin

Question 6

Barret’s esophagus (chronic GI reflux)

Answer 6

Esophageal adenocarcinoma

Question 7

Plummer-Vinson synrome (decrease iron)

Answer 7

SCC of esophagus

Question 8

Cirrhosis (ETOH, HepB, HepC)

Answer 8

Heptaocellular carcinoma

Question 9

UC

Answer 9

Colonic adenocarcinoma

Question 10

Paget’s disease of bone

Answer 10

2” osteosarcoma and fibrosarcoma

Question 11

Immunodeficiency states

Answer 11

Maligant lymphomas

Question 12

AIDS

Answer 12

Aggressive malignant lymphomas (non-H) and Kaposi’s sarcoma

Question 13

Autoimmune disease (Hashimoto’s thyroiditis, myasthenia gravis)

Answer 13

Lymphoma

Question 14

Acanthosis nigricans (hyperpigmentation and epidermal thickening)

Answer 14

Visceral malignancy (stomach, lung, uterus)

Question 15

Dysplastic nevus

Answer 15

Malignant melanoma

Question 16

Radiation exposure

Answer 16

Leukemia, sarcoma, papillary thyroid cancer, breast cancer

Question 17

Associated Tumor

Answer 17

Gene Product

Question 18

abl [GoF]

Answer 18

CML /// Tyrosine Kinase

Question 19

c-myc [GoF]

Answer 19

Burkitt’s lymphoma /// Transcription factor

Question 20

bcl-2 [GoF]

Answer 20

Follicular and undifferentiated lymphomas (inhibits apoptosis) /// Anti-apoptotic molecule

Question 21

HER2/neu (c-erbB2) [GoF]

Answer 21

Breast, ovarian, gastric carcinoma /// Tyrosine kinase

Question 22

ras [GoF]

Answer 22

Colon carcinoma /// GTPase

Question 23

L-myc [GoF]

Answer 23

Lung tumor /// Transcription factor

Question 24

M-myc [GoF]

Answer 24

Neuroblastoma /// Transcription factor

Question 25

ret [GoF]

Answer 25

MEN 2A and 2B /// Tyrosine kinase

Question 26

c-kit [GoF]

Answer 26

Gastrointestinal stromal tumor (GIST) /// Cytokine receptor

Question 27

Rb

Answer 27

Retinoblastoma, osteosarcoma /// Inhibits E2F; blocks G1 --> S phase

Question 28

p53

Answer 28

Most human cancers, Li-fraumeni syndrome /// Transcription factor for p21, blocks GI ---> S phase

Question 29

BRCA1

Answer 29

Breast cancer and ovarian cancer /// DNA repair protein

Question 30

BRCA2

Answer 30

Breast cancer and ovarian cancer /// DNA repair protein

Question 31

p16

Answer 31

Melanoma

Question 32

BRAF

Answer 32

Melanoma /// B-raf

Question 33

APC

Answer 33

Colorectal cancer (associared with FAP)

Question 34

WT1

Answer 34

Wilms' Tumor (nephoblastoma)

Question 35

NF1

Answer 35

NeuroFibromatosis type 1 /// RAS GTPase activating protein (RAS-GAP)

Question 36

NF2

Answer 36

NeuroFibromatosis typer 2 /// Merlin (schwannomin) protein

Question 37

DPC4

Answer 37

Pancreatic cancer /// DPC - deleted in pancreatic cancer

Question 38

DCC

Answer 38

Colon cancer /// Deleted in colon cancer