Specific Toxicity Treatments Flashcards

1
Q

acetaminophen

A

N-acetylcysteine (replenishes glutathione)

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2
Q

AChE inhibitors, organophosphates

A

atropine > pralidoxime

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3
Q

antimuscarinic, anticholinergic agents

A

physostigmine (crosses BBB)

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4
Q

arsenic

A

dimercaprol, succimer

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5
Q

benzodiazepines

A

flumenazil

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6
Q

carbon monoxide

A

100% O2, hyperbaric O2

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7
Q

copper

A

penicillamine, trientine

“3 copper pennies”

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8
Q

cyanide

A

hydroxocobalamin, nitrates + sodium thiosulfate

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9
Q

dabigatran

A

idarucizumab

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10
Q

digoxin

A

digoxin-specific antibody fragments

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11
Q

direct factor Xa inhibitors (e.g., apixaban)

A

andexanet alfa

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12
Q

heparin

A

protamine sulfate

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13
Q

iron

A

deferoxamine, deferasirox, defriprone

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14
Q

lead

A

calcium disodium EDTA, dimercaprol, succimer, penicillamine

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15
Q

mercury

A

dimercaprol, succimer

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16
Q

methanol, ethylene glycol (antifreeze)

A

fomepizole > ethanol, dialysis

17
Q

methemoglobin

A

methylene blue, vitamin C (reducing agent)

18
Q

methotrexate

A

leucovorin

19
Q

opioids

A

naloxone

20
Q

salicylates

A

NaHCO3 (alkalinize urine), dialysis

21
Q

TCAs

A

NaHCO3 (stabilizes cardiac cell membrane)

22
Q

warfarin

A

vitamin K (delayed effect), prothrombin complex concentrate/FFP (immediate effect)