Autoantibodies Flashcards

1
Q

anti-postsynaptic ACh receptor

A

myasthenia gravis

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2
Q

anti-presynaptic voltage-gated calcium channel

A

Lambert-Eaton myasthenic syndrome

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3
Q

anti-B2 glycoprotein I

A

antiphosopholipid syndrome

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4
Q

antinuclear antibody (ANA)

A

nonspecific screening antibody, associated with SLE

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5
Q

anticardiolipin, lupus anticoagulant

A

SLE, antiphospholipid syndrome

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6
Q

anti-dsDNA, anti-Smith

A

SLE

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7
Q

antihistone

A

drug-induced lupus

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8
Q

anti-U1 RNP (ribonucleoprotein)

A

mixed connective tissue disease

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9
Q

rheumatoid factor (IgM antibody against IgG Fc region)

A

rheumatoid arthritis

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10
Q

anti-cyclic citrullinated peptide (anti-CCP)

A

rheumatoid arthritis

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11
Q

anti-Ro/SSA, anti-La/SSB

A

Sjogren syndrome

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12
Q

anti-Scl-70 (anti-DNA topoisomerase I)

A

scleroderma (diffuse)

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13
Q

anticentromere

A

limited scleroderma (CREST syndrome)

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14
Q

antisynthetase (anti-Jo-I), anti-SRUP, anti-helicase (anti-Mi-2)

A

polymyositis, dermatomyositis

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15
Q

antimitochondrial antibody

A

primary biliary cholangitis

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16
Q

anti-smooth muscle, anti-liver/kidney microsomal-1

A

autoimmune hepatitis

17
Q

myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)/ perinuclear ANCA (p-ANCA)

A

microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, ulcerative colitis, primary sclerosing cholangitis

18
Q

PR3-ANCA/ cytoplasmic ANCA (c-ANCA)

A

granulomatosis with polyangiitis

19
Q

anti-phospholipase A2 receptor

A

primary membranous nephropathy

20
Q

anti-hemidesmosome

A

bullous pemphigoid

21
Q

anti-desmoglein (anti-desmosome)

A

pemphigus vulgaris

22
Q

antithyroglobulin, antithyroid peroxidase (antimicrosomal)

A

Hashimoto thyroiditis

23
Q

anti-TSH receptor

A

Graves disease

24
Q

IgA anti-endomysial, IgA anti-tissue transglutaminase, IgA and IgG deamidated gliadin peptide

A

celiac disease

25
Q

anti-glutamic acid decarboxylase, islet cell cytoplasmic antibodies

A

type I diabetes mellitus

26
Q

anti-parietal cell, anti-intrinsic factor

A

pernicious anemia

27
Q

anti-glomerular basement membrane

A

Goodpasture syndrome