Autoantibodies

Question 1

anti-postsynaptic ACh receptor

Answer 1

myasthenia gravis

Question 2

anti-presynaptic voltage-gated calcium channel

Answer 2

Lambert-Eaton myasthenic syndrome

Question 3

anti-B2 glycoprotein I

Answer 3

antiphosopholipid syndrome

Question 4

antinuclear antibody (ANA)

Answer 4

nonspecific screening antibody, associated with SLE

Question 5

anticardiolipin, lupus anticoagulant

Answer 5

SLE, antiphospholipid syndrome

Question 6

anti-dsDNA, anti-Smith

Answer 6

SLE

Question 7

antihistone

Answer 7

drug-induced lupus

Question 8

anti-U1 RNP (ribonucleoprotein)

Answer 8

mixed connective tissue disease

Question 9

rheumatoid factor (IgM antibody against IgG Fc region)

Answer 9

rheumatoid arthritis

Question 10

anti-cyclic citrullinated peptide (anti-CCP)

Answer 10

rheumatoid arthritis

Question 11

anti-Ro/SSA, anti-La/SSB

Answer 11

Sjogren syndrome

Question 12

anti-Scl-70 (anti-DNA topoisomerase I)

Answer 12

scleroderma (diffuse)

Question 13

anticentromere

Answer 13

limited scleroderma (CREST syndrome)

Question 14

antisynthetase (anti-Jo-I), anti-SRUP, anti-helicase (anti-Mi-2)

Answer 14

polymyositis, dermatomyositis

Question 15

antimitochondrial antibody

Answer 15

primary biliary cholangitis

Question 16

anti-smooth muscle, anti-liver/kidney microsomal-1

Answer 16

autoimmune hepatitis

Question 17

myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)/ perinuclear ANCA (p-ANCA)

Answer 17

microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, ulcerative colitis, primary sclerosing cholangitis

Question 18

PR3-ANCA/ cytoplasmic ANCA (c-ANCA)

Answer 18

granulomatosis with polyangiitis

Question 19

anti-phospholipase A2 receptor

Answer 19

primary membranous nephropathy

Question 20

anti-hemidesmosome

Answer 20

bullous pemphigoid

Question 21

anti-desmoglein (anti-desmosome)

Answer 21

pemphigus vulgaris

Question 22

antithyroglobulin, antithyroid peroxidase (antimicrosomal)

Answer 22

Hashimoto thyroiditis

Question 23

anti-TSH receptor

Answer 23

Graves disease

Question 24

IgA anti-endomysial, IgA anti-tissue transglutaminase, IgA and IgG deamidated gliadin peptide

Answer 24

celiac disease

Question 25

anti-glutamic acid decarboxylase, islet cell cytoplasmic antibodies

Answer 25

type I diabetes mellitus

Question 26

anti-parietal cell, anti-intrinsic factor

Answer 26

pernicious anemia

Question 27

anti-glomerular basement membrane

Answer 27

Goodpasture syndrome