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Step 1 - Quick Decks > Drug Reactions > Flashcards

Drug Reactions Flashcards

1
Q

coronary vasospasm

A

cocaine, amphetamines, sumatriptan, ergot alkaloids

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2
Q

cutaneous flushing

A

Vancomycin, Adenosine, Niacin, Calcium channel blockers, Echinocandins, Nitrates

“flushed from VANCEN [dancing]”

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3
Q

dilated cardiomyopathy

A

alcohol, anthracycline (doxorubicin, daunorubicin; prevent with dexrazoxane), trastuzumab

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4
Q

torsades de pointes

A

agents that prolong the QT interval: antiArrhythmics (class IA, III), antiBiotics (macrolides, fluoroquinolones), anti”C”ychotics (ziprasidone), antiDepressants (TCAs), antiEmetics (ondansetron), antiFungals (fluconazole)

“ABCDEF”

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5
Q

andrenocortical insufficiency

A

HPA suppression secondary to glucocorticoid withdrawal

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6
Q

diabetes insipidus

A

lithium, demeclocycline

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7
Q

gynecomastia

A

ketoconazole, cimetidine, spironolactone, GnRH analogs/antagonists, androgen receptor inhibitors, 5-alpha-reductase inhibitors

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8
Q

hot flashes

A

SERMs (tamoxifen, clomiphene, raloxifene)

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9
Q

hyperprolactinemia

A

typical antipsychotics (haloperidol), atypical antipsychotics (risperidone), metoclopramide, methyldopa, reserpine

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10
Q

hyperthyroidism

A

amiodarone, iodine, lithium

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11
Q

hypothyroidism

A

amiodarone, lithium

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12
Q

SIADH

A

carbamazepine, cyclophosphamide, SSRIs

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13
Q

acute cholestatic hepatitis, jaundice

A

macrolides (erythromycin)

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14
Q

diarrhea

A

acamprosate, antidiabetic agents, colchicine, cholinesterase inhibitors, lipid-lowering agents, macrolides, SSRIs, chemotherapy

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15
Q

focal to massive hepatic necrosis

A

halothane, Amanita phalloides (death cap mushroom), valproate, acetaminophen

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16
Q

hepatitis

A

rifampin, isoniazid, pyrazinamide, statins, fibrates

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17
Q

pacreatitis

A

Didanosine, Glucocorticoids, Alcohol, Valproate, Azathioprine, Diuretics (furosemide, HCTZ)

“Drugs Generate A Violent Abdominal Distress”

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18
Q

pill-induced esophagitis

A

Potassium chloride, NSAIDs, Bisphosphonates, Ferrous sulfate, Tetracyclines

“Pills Not Beneficial for Food Tube”

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19
Q

pseudomembranous colitis

A

ampicillin, cephalosporins, clindamycin, fluoroquinolones, PPIs

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20
Q

agranulocytosis

A

Dapsone, Clozapine, Carbamazepine, Propylthiouracil, Methimazole, Colchicine, Ticlopidine, Ganciclovir

“Drugs Can Cause Pretty Major Collapse To Granulocytes”

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21
Q

aplastic anemia

A

Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propylthiouracil

“Can’t Make New Blood Cells Properly”

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22
Q

direct Coombs positive hemolytic anemia

A

penicillin, methyldopa, cephalosporins

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23
Q

drug reaction with eosinophilia and systemic symptoms

A

phenytoin, carbamazepine, minocycline, sulfa drugs, allopurinol, vancomycin

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24
Q

gray baby syndrome

A

chloramphenicol

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25
hemolysis in G6PD deficiency
isoniazid, sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin
26
megaloblastic anemia
hydroxyurea, phenytoin, methotrexate, sulfa drugs "You're having a mega blast with PMS"
27
thrombocytopenia
indinavir, heparin, quinidine, ganciclovir, vancomycin, linezolid, abciximab "I Have Quickly Gotten Very Low Amounts"
28
thrombotic complications
combined oral contraceptives, hormone replacement therapy, SERMs, epoetin alfa
29
drug-induced lupus
methyldopa, minocycline, hydralazine, isoniazid, phenytoin, sulfa drugs, etanercept, procainamide "Lupus Makes My HIPS Extremely Painful"
30
fat redistribution
protease inhibitors, glucocorticoids
31
gingival hyperplasia
cyclosporine, calcium channel blockers, phenytoin
32
hyperuricemia (gout)
pyrazinamide, thiazides, furosemide, niacin, cyclosporine
33
myopathy
statins, fibrates, niacin, colchicine, daptomycin, hydroxychloroquine, interferon-alpha, penicillamine, glucocorticoids
34
osteoporosis
glucocorticoids, depot medroxyprogesterone acetate, GnRH agonists, aromatase inhibitors, anticonvulsants, heparin, PPIs
35
photosensitivity
sulfonamides, amiodarone, tetracyclines, 5-FU
36
rash (Steven-Johnson syndrome)
antiepileptic drugs (especially lamotrigine), allopurinol, sulfa drugs, penicillin
37
teeth discoloration
tetracyclines
38
tendon/cartilage damage
fluoroquinolones
39
cinchonism
quinidine, quinine cinchonism = tinnitus, hearing/vision loss, psychosis, cognitive impairment
40
Parkinson-like sydrome
antipsychotics, reserpine, metoclopramide
41
peripheral neuropathy
platinum agents (cisplatin), isoniazid, vincristine, paclitaxel, phenytoin
42
idiopathic intracranial hypertension
vitamin A, growth hormones, tetracyclines
43
seizures
isoniazid, bupropion, imipenem/cilastatin, tramadol, enflurane
44
tardive dyskinesia
antipsychotics, metoclopramide
45
visual disturbances
-topiramate (blurred vision/diplopia, haloes) -hydroxychloroquine (decreased visual acuity, visual field defects) -digoxin (yellow-tinged vision) -isoniazid (optic neuritis) -ivabradine (luminous phenomena) -vigabatrin (visual field defects) -PDE-5 inhibitors (blue-tinged vision) -ethambutol (color vision changes) "These Horrible Drugs Irrevocably Irritate Very Precious Eyes"
46
Fanconi syndrome
cisplatin, ifosfamide, expired tetracyclines, tenofovir
47
hemorrhagic cystitis
cyclophosphamide, ifosfamide
48
interstitial nephritis
diuretics, NSAIDs, penicillins and cephalosporins, PPIs, rifampin, sulfa drugs
49
dry cough
ACE inhibitors
50
pulmonary fibrosis
methotrexate, nitrofurantoin, carmustine, bleomycin, busulfan, amiodarone "My Nose Cannot Breathe Bad Air"
51
antimuscarinic effects
atropine, TCAs, H1-blockers, antipsychotics
52
disulfiram-like reaction
1st generation sulfonylureas, procarbazine, certain cephalosporins, griseofulvin, metronidazole "Sorry Pals, Can't Go Mingle"
53
nephrotoxicity/ototoxicity
loop diuretics, cisplatin, aminoglycosides, amphotericin, vancomycin "Listen Cis, Always Adjust vancomycin in CKD"
54
mydriasis
anticholinergics (atropine, TCAs, tropicamide, scopolamine, antihistamines), indirect sympathomimetics (amphetamines, cocaine, LSD), meperidine, direct sympathomimetics
55
miosis
sympatholytics (alpha-2 agonists), opioids (except meperidine), parasympathomimetics (pilocarpine), organophosphates
56
cytochrome P450 inducers
St. John's wort, Phenytoin, Phenobarbital, Modafinil, Nevirapine, Rifampin, Griseofulvin, Carbamazepine, Chronic alcohol overuse "St. John's funny funny mom never refuses greasy carbs and chronic alcohol"
57
cytochrome P450 substrates
Theophylline, OCPs, Anti-epileptics, Warfarin "The OCPs are anti-war"
58
cytochrome P450 inhibitors
Sodium valproate, Isoniazid, Cimetidine, Ketoconazole, Fluconazole, Acute alcohol overuse, Chloramphenicol, Erythromycin/clarithromycin, Sulfonamides, Ciprofloxacin, Omeprazole, Amiodarone, Ritonavir, Grapefruit juice "SICK FACES COme when I AM Really drinking Grapefruit juice"
59
sulfa drugs
Sulfonamide antibiotics, Sulfasalazine, Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonylureas "Scary Sulfa Pharm FACTS"
60
antimicrobials to avoid in pregnancy

Step 1 - Quick Decks (18 decks)

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