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Step 1 - Quick Decks > Cytokines, Cell Surface Proteins > Flashcards

Cytokines, Cell Surface Proteins Flashcards

1
Q

HLA associations: B27

A

psoriatic arthritis, ankylosing spondylitis, IBD-associated arthritis, reactive arthritis

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2
Q

HLA associations: B57

A

abacavir hypersensitivity

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3
Q

HLA associations: DQ2/DQ8

A

celiac disease

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4
Q

HLA associations: DR3

A

DM type 1, SLE, Graves disease, Hashimoto thyroiditis, Addison disease

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5
Q

HLA associations: DR4

A

rheumatoid arthritis, DM type 1, Addison disease

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6
Q

IL-1

A

causes fever, acute inflammation; activates endothelium to expression adhesion molecules; recruits WBCs; also called osteoclast-activating factor

IL-1, IL-6, and TNF-alpha can mediated fever and sepsis

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7
Q

IL-6

A

causes fever and stimulates production of acute-phase proteins

IL-1, IL-6, and TNF-alpha can mediated fever and sepsis

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8
Q

TNF-alpha

A

activates endothelium; WBC recruitment, vascular leak

causes cachexia in malignancy; maintains granulomas in TB

IL-1, IL-6, and TNF-alpha can mediated fever and sepsis

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9
Q

IL-8

A

chemotactic factor for neutrophils

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10
Q

IL-12

A

induces T cell differentiation into Th1 cells; activates NK cells

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11
Q

IL-2

A

stimulate growth of helper, cytotoxic, and regulatory T cells and NK cells

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12
Q

IL-3

A

supports growth and differentiation of bone marrow stem cells; functions like GM-CSF

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13
Q

INF-gamma

A

secreted by NK cells and T cells in response to antigen or IL-12 from macrophages

stimulates macrophages to kill phagocytosed pathogens; inhibits differentiation of Th2 cells; induces IgG isotype switching; increases MHC expression

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14
Q

IL-4

A

induces differentiation of T cells into Th2 cells; promotes growth of B cells; enhances IgE class switching

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15
Q

IL-5

A

promotes growth and differentiation of B cells; enhances class switching to IgA; stimulates growth/differentiation of eosinophils

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16
Q

IL-10

A

attenuates inflammatory response; decreases expression of MHC class II and Th1 cytokines; inhibits activated macrophages and dendritic cells

secreted by T regulatory cells

17
Q

IL-13

A

promotes IgE production; induces alternative macrophage activation

18
Q

T cell surface proteins

A

TCR, CD3, CD28

TCR binds antigen-MHC complex, CD3 is associated with TCR for signal transduction, CD28 binds B7 on APC

19
Q

helper T cell surface proteins

A

CD4, CD40L, CXCR4/CCR5 (coreceptors for HIV)

20
Q

cytotoxic T cell surface proteins

21
Q

regulatory T cell surface proteins

22
Q

B cell surface proteins

A

Ig (binds antigen), CD19, CD20, CD21 (receptor for EBV), CD40, MHC II, B7 (CD80/86)

23
Q

NK cell surface proteins

A

CD16 (binds Fc of IgG), CD56

24
Q

macrophage surface proteins

A

CD14 (receptor for PAMPs), CD40, CCR5, MHC II, B7, Fc and C3b receptors

25
Q

hematopoietic stem cell surface proteins

Step 1 - Quick Decks (18 decks)

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