Somatic therapies II Flashcards
what are the types of anxiolytics? which is most prescribed?
- antidepressants
- benzos (most prescribed)
- buspirone
- antihistamines
MOA of benzos
potentiates actions of GABA - direct anxiolytic effect in limbic system
what are the side effects of benzos?
- CNS depression
- abuse potential
- caution alcohol / drug abuse history / dependence
are benzos safe during pregnancy? what about breast feeding?
- pregnancy: yes, generally
- breastfeeding: no
what is the approved use for buspirone? what is the MOA?
- anxiety
- dendritic 5HT1 agonist
what should be used to treat long term conditions such as panic disorder or GAD? if first line fails?
- SSRIs
- second line: SNRIs, mirtazapine
what should be used for acute anxiety?
benzos
can buspirone be used PRN?
NO
what is the antipsychotic MOA? what about the second generations?
- postsynaptic D2 receptor blockade
- weaker D2 antagonists
- potent 5HT2A antagonists
- higher 5HT2A / D2 affinity than FGA
what is that standard of care for first generation antipsychotics? what are the approved uses?
- any condition with psychotic symptoms / agitation / aggression
- schizo, psychosis, agitation, n/v, tourettes
what is the first line for acute psychosis or agitation?
high potency
what are the antipsychotic side effects?
- anticholinergic
- a-adrenergic
- QT prolongation
- agranulocytosis
- hyperprolactinemia
is NMS dose related?
no
what are the symptoms for NMS?
- rigidity
- fever
- delirium
- autonomic instability
- serum CPK and liver enzymes elevated
treatment for NMS?
- dantrolene (first line)
- DA agonists (bromocriptine)
