somatic therapies

Question 1

metabolism of SSRI

Answer 1

hepatic

Question 2

lethargy, restlessness, mental confusion, flushing, diaphoresis, termor

Answer 2

serotonin syndrome

Question 3

serotonin occurs when what are combined

Answer 3

> 1 SSRI, or MAOi

Question 4

subclinical serotonin syndrome

Answer 4

mild cognitive complaints, mild tremor, diaphoresis

Question 5

at lower doses, venlafaxine acts on_____, at higher doses it acts on_____

Answer 5

inhibits serotonin reuptake; inhibits NE and DA reuptake

Question 6

high doses of venlafaxine assc’d with what SE?

Answer 6

sedation

Question 7

which med is very sensitive to discontinuation syndrome

Answer 7

venlafaxine

Question 8

buproprion MOA

Answer 8

weak reuptake inhib of DA and NE

Question 9

at doses >450 of wellbutrin, what SE may occur?

Answer 9

seizure

Question 10

MOA of vilazodone

Answer 10

SSRI and 5HT receptor partial agonist

Question 11

MOA of trazadone

Answer 11

weak inhibitor of serotonin + blocks 5HT2 receptors

Question 12

utilization of trazadone

Answer 12

sleep agent

Question 13

MOA of mirtazapine

Answer 13

antag at postsynaptic 5HT2, 5HT3, central alpha1

Question 14

uses of mirtazapine

Answer 14

MDD, sleep aid

Question 15

what class is chlomipramine

Answer 15

TCA

Question 16

what makes chlomipramine stand out from other TCA

Answer 16

relatively selective serotonin reuptake inhib

Question 17

anxiety, irritability, insomnia, HA, nausea, malaise, motor disturbance

Answer 17

discontinuation syndrome

Question 18

does melancholic depression or bipolar depression respond better to meds

Answer 18

melancholic depression

Question 19

choice med for tx of MDD during pregnancy

Answer 19

sertraline

Question 20

the most widely prescribed class of psychotropic drugs

Answer 20

benzos

Question 21

tx of OCD

Answer 21

1. higher doses SSRI

2. clomipramine

Question 22

MOA of benzos

Answer 22

GABA agonist

Question 23

buspirone is effective in treating what type of anxiety

Answer 23

GAD

Question 24

MOA of buspirone

Answer 24

dendritic 5HT agonist

Question 25

1st line fro acute psychosis

Answer 25

high potency SGA or haloperidol

Question 26

muscle rigidity, high fever, delirium, autonomic instability, elevated serum CPK and LFT

Answer 26

neuroleptic malignant syndrome

Question 27

tx of neuroleptic malignant syndrome

Answer 27

1. stop med

2. bromocriptine

Question 28

occurs within 1st 4 days of antipsychotic administration, sustained contraction of neck muscles

Answer 28

acute dystonic rxn

Question 29

tx of acute dystonia

Answer 29

benztropine or diphenhydramine

Question 30

can occur within 1st few weeks of antipsychotic initiation, anxiety, tension, restlessness, agiatation

Answer 30

akathesia

Question 31

tx of akathesia

Answer 31

propranolol

Question 32

black box warning with risperidone

Answer 32

incr CVA

Question 33

most effective and least tolerated SGA

Answer 33

clozapine

Question 34

risk of agranulocytosis assc’d with?

Answer 34

clozapine

Question 35

antipsychotic Least likely to cause weight gain

Answer 35

ariprazole

Question 36

what has been shown to minimize weight gain in ppl on antipsychotics

Answer 36

metformin

Question 37

SE: Hypothyroidism, polyuria/polydipsia, tremor, nausea, weight gain, edema - what drug?

Answer 37

lithium

Question 38

mental status changes, ataxia, dehydration, hyponatremia

Answer 38

lithium toxicity

Question 39

most effective tx for depression

Answer 39

ECT

Question 40

which SNRI is indicated for ADHD

Answer 40

atomoxetine