neurocog disorders Flashcards
major NCD have ____decline, mild NCD have____decline
significant; modest
domains evaluated for NCD (6)
- complex attn
- executive fxn
- learning/memory
- language
- perceptual motor
- social cognition
risk factors for AD (4)
- advanced age
- famhx
- down’s syndrome
- apolipoprotein E4
neurofibrillay tangles, neuritic plaques, excess amyloid
only things that can definitively dx AD
binswanger’s disease
vascular disease/multi-infarct dementia
2nd most common type of dementia
multi-infarct dementia
subclinical parkinsonism, psychosis, autonomic dysfxn, gradual progressive cognitive impairment
lewy body disease
tx of lewy body disease
cholinesterase inhibs
what must be avoided in tx of lewy body disease
antipsychotics
impairment of the temporal and frontal lobes; occurs in 50’s, disinhibition/apathy, language problems, steadily progressive
pick’s disease (frontotemporal disease)
mild repetitive concussions, followed 8-10 yrs later by neuropsych sx
chronic traumatic encephalopathy
types of subcortical disease (4)
- PD
- MS
- HD
- vascular disease
huntington’s is what mode of inheritance
autosomal dominant
choreoathtoid movements, changes in mood/personality, flat affect, rapid & soft speech
HD
triad of normal pressure hydrocephalus
- confusion
- ataxic gait
- urinary incontinence
how to determine if ventriculo-peritoneal shunt is beneficial for tx of normal pressure hydrocephalus
LP
once traumatic brain injury is stabilized and it doesn’t improve
static encephalopathy
tx of wernicke’s encephalopathy
thiamine
delirium, ocular changes, gait disturbance in alcoholics
wernicke’s encephalopathy
what is mahor/mild neurocognitive disorder, amnestic-confabulatory type
korsakoff’s syndrome
rash, fatigue, HA, focal neuro signs, encephalitis, cognitive sx
lyme disease
tx of lyme disease
Abx
onset middle-old age, psych disturbances, tremor
cruetzfeldt-jakob
develops over a short period and fluctuates
delirium
____% hospitalized patients are affected by delirium
30%
risk factors for delirium (4)
- age
- nursing home
- pre-existing brain damage
- male
tx of MCI
encourage catastrophization
initial labs for NCD
- CBC
- CMP
- Vit B12
- thyroid studies
what genes can be assessed for early onset AD
Prensilin 1/2, APP
who determines decision making capacity
attending physician
sexually inappropriate patients can be tx’d with?
antidepressants
antipsychotics are assc’d with ____in dementia patients
higher mortality rate
carbamazepine can be used for what type of patients
manic, explosive
tx of cognitive sx (2)
- ACHe inhibs
2. memantine
MOA of memantine
NMDA receptor antag