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Smooth Muscle Drugs Flashcards

1
Q

Nitroglycerine acts on which tissues or organs?

A

Veins (major), arteries (minor)

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2
Q

What effects does Nitroglycerine have?

A

Vasodilation (decrease pre-load)

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3
Q

Nitroglycerine will increase or decrease pre-load?

A

Decrease pre-load

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4
Q

Side effects of Nitroglycerin?

A

Hypotension

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5
Q

Mechanism of Nitroglycerin?

A

NO —> cGMP which causes vasodialation

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6
Q

Uses of Nitroglycerin?

A

for heart fail patients

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7
Q

Nitroprusside acts on which tissues or organs?

A

Veins (major), arteries (minor)

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8
Q

What effects does Nitroprusside have?

A

Vasodilation (decreases pre-load)

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9
Q

Nitroprusside will increase or decrease pre-load?

A

Decrease pre-load

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10
Q

Side effects of Nitroprusside?

A

Hypotension

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11
Q

Mechanism of Nitroprusside?

A

NO–>cGMP which causes vasodialation

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12
Q

Uses of Nitroprusside?

A

heart fail patients

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13
Q

Hydralazine acts on which receptor?

A

Increase cGMP (mechanism unknown) thus vasodialation

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14
Q

Hydralazine acts on which tissue?

A

Arteries

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15
Q

What effects do Hydralazine have on arteries?

A

Vasodilation (decrease TPR/afterload)

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16
Q

Hydralizine is used for?

A

heart failure

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17
Q

Negative side effects of Hydralizine?

A

Hypotension

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18
Q

Hydralizine is venous or arterial dominant?

A

Arterial dominant (decrease TPR)

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19
Q

Hydralizine will increase or decrease TPR?

A

decrease TPR

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20
Q

What are the uses of Minoxidil?

A

Heart failure, HTN, (Rogaine - male pattern baldness)

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21
Q

This helps with male pattern baldness

A

Minoxidil

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22
Q

Drug for Heart fail, HTN, male pattern baldness

A

Minoxidil

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23
Q

Minoxidil acts on arteries or veins

A

Arteries

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24
Q

K+ channel opener (ATP sensitive), (possible) NO donor

A

Minoxidil

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25
What effect does Minoxidil have on TRP and after load?
Decreases
26
Diazoxide acts on which receptor?
K+ channel opener
27
What does Diazoxide act on?
arteries and veins
28
Diazoxide will vasodialator or vasoconstrict
Vasodialtion
29
When would we prescribe Diazoxide to a patient?
for HTN
30
Diazoxide works best for arteries or veins?
for BOTH!
31
What are my 2 Ca+ channel blockers?
Verapamil and Diltiazem
32
ACE inhibitors act on arteries/veins/both
both
33
MEchanism of ACE inhibitors
1) Block ACE / conversion of Ang1 to Ang2 | 2) block catabolism of bradykinin
34
1) Block ACE / conversion of Ang1 to Ang2 | 2) block catabolism of bradykinin
ACE inhibitors
35
Drug that acts as a K+ channel opener
Diazoxide
36
ACE inhibitors can be used to treat what?
HTN
37
Fenoldopam Works by:
Increase RBF --> water loss --> decrease in BP
38
Dopamine A1 receptor agonist
Fenoldopam
39
Fenoldopam acts on what receptor
Fenoldopam
40
Fenoldopam acts on arteries/veins or both
Arteries & veins (Increase RBF)
41
What affect does Fenoldopam have on RBF?
Increases RBF
42
What are the EFFECTS Fenoldopam on Smooth muslce cAMP?
Increase SMC cAMP.
43
Fenoldopam has a direct effect _______ | and an indirect effect_______
Direct: A1 activates D1 receptor; Indirect: A1 activates Adenosine receptor
44
Use of Fenoldopam
HTN crisis
45
Drug used for HTN crisis
Fenoldopam
46
aplah-adrenergic blocker used to treat HTN
Prazosin
47
Effect of Prazosin on vessels
Blocks sympathetic (NE) effects on vessels
48
This drug blocks sympathetic (NE) effects on vessels
Prazosin
49
Prazosin acts on arteries/veins or both
both
50
Albuterol, Pirbuterol, Terbutaline, Salmeterol, Formoterol are all
B2 agonists... Bronochodialators
51
What are my bronchodialators
``` FAST-P Formoterol Albuterol Salmeterol Terbutaline Pirbuterol ```
52
Uses of my B2 agonists
prevent wheezing, shortness of breath, coughing, and chest tightness caused by asthma and chronic obstructive pulmonary disease
53
Mechanism of Albuterol
Increase SMC cAMP -> Bronchodilation
54
Mechanism of Salmeterol
Increase SMC cAMP -> Bronchodilation
55
Mech of Formoterol
Increase SMC cAMP -> Bronchodilation
56
Mech of Pirbuterol
Increaes SMC cAMP-->BroncoD
57
Mech of Terbutaline
Increase SMC cAMP -> Bronchodilation
58
Side effects of B2 agonists
Cardiotoxicity (B2 in heart --> cAMP --> tachycardia, contractility)
59
These drugs cause cardiotoxicity and we see tachycardia and increased contractility
``` B2 agonists Formoterol Albuterol Salmeterol Tirbutaline Pirbuterol ```
60
Route of administration for B2 agonists
inhalation
61
Ipratropium and Tiotropium act on which receptors
M2 and M3 antagonist
62
M2 and M3 antagonist
Ipratropium and Tiotropium
63
Ipratropium/Tiotropium's mechanism to cause Bronchodialation
Inhibit Ach/parasympathetic induced contraction
64
Ipatropium/Tiotropium will also have this affect besides bronchodialations
will decrease mucus secreation
65
Anti-cholinergic Bronchodialtors
Ipratropium and Tiotropium
66
Mechanism of action for Theophylline and Aminophylline
1) Blocks adenosine's constriction. | 2) Blocks PDE3 --> increasing cAMP --> relaxation
67
1) Blocks adenosine's constriction. | 2) Blocks PDE3 --> increasing cAMP --> relaxation
Theophylline and Aminophylline
68
My 2 adenosine receptor antagonists
Theophylline and Aminophylline
69
Also increases: mucocilliary clearance, resp. muscle strength. Decreaes: plasma exudation, neutrophil fn, Tcell fn, macrophage fn
Theophylline and Aminophylline
70
What affects do Theophylline and Aminophylline have on Mucocilliary clearance and Respiratory muscle strength
Increase both mucociliary clearance and increases respiratory muscle strenghth
71
Theophylline and Aminophylline cause Phosphodiesterase ________ and Adenosine Receptor _________
Inhibition | Antagonism
72
Milrinone, Inamrinone, Cilostazol are all
Phosphodiesterase 3 inhibitors
73
Milrionone, Inamrinone and Cilostazol act on
Arteries and the Heart
74
What 2 effects do our PDE3 inhibitors have | Milrinone, Inamrinone, Cilostazol
1) Vasodilation (decrease TPR/afterload) | 2) Increase HR & contractility
75
1) Vasodilation (decrease TPR/afterload) | 2) Increase HR & contractility
Milrinone, Inamrinone, Cilostazol
76
PDE3 inhibitors used to treat heart fail patients
Milrinone, Inamrinone, Cilostazol
77
What affect do PDE 3 inhibitors have on cAMP leves?
Increases them... PDE3 converts cAMP--> AMP | cAMP is what will increase HR and increase contractility... something heart fail patients need
78
Sildenafil and Tadalafil are used to...
tx erectile dysfuntion
79
Sildenafil and Tadalafil mechanism of action
PDE5 inhibitor which will prevent the break down of cGMP--> GMP cGMP is responsible for smooth muslce relaxation = boner
80
PDE5 inhibitor which will prevent the break down of cGMP--> GMP cGMP is responsible for smooth muslce relaxation = boner
Sildenafil and Tadalafil
81
two smooth msl relaxants that tx erectile dysfunction
sildenafil and tadalafil

Block 2 Drugs (10 decks)

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