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Block 2 Drugs > Smooth Muscle Drugs > Flashcards

Smooth Muscle Drugs Flashcards

1
Q

Nitroglycerine acts on which tissues or organs?

A

Veins (major), arteries (minor)

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2
Q

What effects does Nitroglycerine have?

A

Vasodilation (decrease pre-load)

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3
Q

Nitroglycerine will increase or decrease pre-load?

A

Decrease pre-load

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4
Q

Side effects of Nitroglycerin?

A

Hypotension

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5
Q

Mechanism of Nitroglycerin?

A

NO —> cGMP which causes vasodialation

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6
Q

Uses of Nitroglycerin?

A

for heart fail patients

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7
Q

Nitroprusside acts on which tissues or organs?

A

Veins (major), arteries (minor)

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8
Q

What effects does Nitroprusside have?

A

Vasodilation (decreases pre-load)

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9
Q

Nitroprusside will increase or decrease pre-load?

A

Decrease pre-load

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10
Q

Side effects of Nitroprusside?

A

Hypotension

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11
Q

Mechanism of Nitroprusside?

A

NO–>cGMP which causes vasodialation

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12
Q

Uses of Nitroprusside?

A

heart fail patients

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13
Q

Hydralazine acts on which receptor?

A

Increase cGMP (mechanism unknown) thus vasodialation

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14
Q

Hydralazine acts on which tissue?

A

Arteries

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15
Q

What effects do Hydralazine have on arteries?

A

Vasodilation (decrease TPR/afterload)

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16
Q

Hydralizine is used for?

A

heart failure

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17
Q

Negative side effects of Hydralizine?

A

Hypotension

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18
Q

Hydralizine is venous or arterial dominant?

A

Arterial dominant (decrease TPR)

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19
Q

Hydralizine will increase or decrease TPR?

A

decrease TPR

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20
Q

What are the uses of Minoxidil?

A

Heart failure, HTN, (Rogaine - male pattern baldness)

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21
Q

This helps with male pattern baldness

A

Minoxidil

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22
Q

Drug for Heart fail, HTN, male pattern baldness

A

Minoxidil

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23
Q

Minoxidil acts on arteries or veins

A

Arteries

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24
Q

K+ channel opener (ATP sensitive), (possible) NO donor

A

Minoxidil

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25
Q

What effect does Minoxidil have on TRP and after load?

A

Decreases

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26
Q

Diazoxide acts on which receptor?

A

K+ channel opener

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27
Q

What does Diazoxide act on?

A

arteries and veins

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28
Q

Diazoxide will vasodialator or vasoconstrict

A

Vasodialtion

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29
Q

When would we prescribe Diazoxide to a patient?

A

for HTN

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30
Q

Diazoxide works best for arteries or veins?

A

for BOTH!

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31
Q

What are my 2 Ca+ channel blockers?

A

Verapamil and Diltiazem

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32
Q

ACE inhibitors act on arteries/veins/both

A

both

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33
Q

MEchanism of ACE inhibitors

A

1) Block ACE / conversion of Ang1 to Ang2

2) block catabolism of bradykinin

34
Q

1) Block ACE / conversion of Ang1 to Ang2

2) block catabolism of bradykinin

A

ACE inhibitors

35
Q

Drug that acts as a K+ channel opener

A

Diazoxide

36
Q

ACE inhibitors can be used to treat what?

A

HTN

37
Q

Fenoldopam Works by:

A

Increase RBF –> water loss –> decrease in BP

38
Q

Dopamine A1 receptor agonist

A

Fenoldopam

39
Q

Fenoldopam acts on what receptor

A

Fenoldopam

40
Q

Fenoldopam acts on arteries/veins or both

A

Arteries & veins (Increase RBF)

41
Q

What affect does Fenoldopam have on RBF?

A

Increases RBF

42
Q

What are the EFFECTS Fenoldopam on Smooth muslce cAMP?

A

Increase SMC cAMP.

43
Q

Fenoldopam has a direct effect _______

and an indirect effect_______

A

Direct: A1 activates D1 receptor;
Indirect: A1 activates Adenosine receptor

44
Q

Use of Fenoldopam

A

HTN crisis

45
Q

Drug used for HTN crisis

A

Fenoldopam

46
Q

aplah-adrenergic blocker used to treat HTN

A

Prazosin

47
Q

Effect of Prazosin on vessels

A

Blocks sympathetic (NE) effects on vessels

48
Q

This drug blocks sympathetic (NE) effects on vessels

A

Prazosin

49
Q

Prazosin acts on arteries/veins or both

A

both

50
Q

Albuterol, Pirbuterol, Terbutaline, Salmeterol, Formoterol are all

A

B2 agonists… Bronochodialators

51
Q

What are my bronchodialators

A 
FAST-P
Formoterol
Albuterol
Salmeterol
Terbutaline
Pirbuterol
52
Q

Uses of my B2 agonists

A

prevent wheezing, shortness of breath, coughing, and chest tightness caused by asthma and chronic obstructive pulmonary disease

53
Q

Mechanism of Albuterol

A

Increase SMC cAMP -> Bronchodilation

54
Q

Mechanism of Salmeterol

A

Increase SMC cAMP -> Bronchodilation

55
Q

Mech of Formoterol

A

Increase SMC cAMP -> Bronchodilation

56
Q

Mech of Pirbuterol

A

Increaes SMC cAMP–>BroncoD

57
Q

Mech of Terbutaline

A

Increase SMC cAMP -> Bronchodilation

58
Q

Side effects of B2 agonists

A

Cardiotoxicity (B2 in heart –> cAMP –> tachycardia, contractility)

59
Q

These drugs cause cardiotoxicity and we see tachycardia and increased contractility

A 
B2 agonists
Formoterol
Albuterol
Salmeterol
Tirbutaline
Pirbuterol
60
Q

Route of administration for B2 agonists

A

inhalation

61
Q

Ipratropium and Tiotropium act on which receptors

A

M2 and M3 antagonist

62
Q

M2 and M3 antagonist

A

Ipratropium and Tiotropium

63
Q

Ipratropium/Tiotropium’s mechanism to cause Bronchodialation

A

Inhibit Ach/parasympathetic induced contraction

64
Q

Ipatropium/Tiotropium will also have this affect besides bronchodialations

A

will decrease mucus secreation

65
Q

Anti-cholinergic Bronchodialtors

A

Ipratropium and Tiotropium

66
Q

Mechanism of action for Theophylline and Aminophylline

A

1) Blocks adenosine’s constriction.

2) Blocks PDE3 –> increasing cAMP –> relaxation

67
Q

1) Blocks adenosine’s constriction.

2) Blocks PDE3 –> increasing cAMP –> relaxation

A

Theophylline and Aminophylline

68
Q

My 2 adenosine receptor antagonists

A

Theophylline and Aminophylline

69
Q

Also increases: mucocilliary clearance, resp. muscle strength.
Decreaes: plasma exudation, neutrophil fn, Tcell fn, macrophage fn

A

Theophylline and Aminophylline

70
Q

What affects do Theophylline and Aminophylline have on Mucocilliary clearance and Respiratory muscle strength

A

Increase both mucociliary clearance and increases respiratory muscle strenghth

71
Q

Theophylline and Aminophylline cause
Phosphodiesterase ________ and
Adenosine Receptor _________

A

Inhibition

Antagonism

72
Q

Milrinone, Inamrinone, Cilostazol are all

A

Phosphodiesterase 3 inhibitors

73
Q

Milrionone, Inamrinone and Cilostazol act on

A

Arteries and the Heart

74
Q

What 2 effects do our PDE3 inhibitors have

Milrinone, Inamrinone, Cilostazol

A

1) Vasodilation (decrease TPR/afterload)

2) Increase HR & contractility

75
Q

1) Vasodilation (decrease TPR/afterload)

2) Increase HR & contractility

A

Milrinone, Inamrinone, Cilostazol

76
Q

PDE3 inhibitors used to treat heart fail patients

A

Milrinone, Inamrinone, Cilostazol

77
Q

What affect do PDE 3 inhibitors have on cAMP leves?

A

Increases them… PDE3 converts cAMP–> AMP

cAMP is what will increase HR and increase contractility… something heart fail patients need

78
Q

Sildenafil and Tadalafil are used to…

A

tx erectile dysfuntion

79
Q

Sildenafil and Tadalafil mechanism of action

A

PDE5 inhibitor which will prevent the break down of cGMP–> GMP
cGMP is responsible for smooth muslce relaxation = boner

80
Q

PDE5 inhibitor which will prevent the break down of cGMP–> GMP
cGMP is responsible for smooth muslce relaxation = boner

A

Sildenafil and Tadalafil

81
Q

two smooth msl relaxants that tx erectile dysfunction

A

sildenafil and tadalafil

Block 2 Drugs (10 decks)

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