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Block 2 Drugs > Eicasanoids drugs > Flashcards

Eicasanoids drugs Flashcards

1
Q

Dinoprostone is a _____ analogue

A

PGE2

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2
Q

Activation of collagenase [breakdown of collagen], also relaxes cervical smooth muscle

A

Dinoprostone

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3
Q

Causes cervical ripening in pregnancy

A

Dinoprostone

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4
Q

Zileuton works by:

A

inhibitor of 5-lipoxygenase

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5
Q

Mechanism of Zileuton

A

inhibits cys-LTs (bronchoconstriction and
increase vascular permeability and LTB4
(chemotaxis)

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6
Q

Administration of Zileuton

A

Oral with half life of 2.5 hours

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7
Q

Pharmakokinetics of Zileuton

A

metabolized by CYPs

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8
Q

Use of Zileuton

A

prophylaxis tx of asthma

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9
Q

cysteinyl leukotriene receptor antagonists

A

Zafirlukast

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10
Q

inhibits cys-LTs (bronchoconstriction and
increase vascular permeability and LTB4
(chemotaxis)

A

Zileuton

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11
Q

What drug inhibits 5-lipoxygenase

A

Zileuton

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12
Q

Metabolism of Zarfirlukast

A

CYP2C9

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13
Q

Zarfirlukast works by:

A

inhibitiing cys-leukotriene receptor

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14
Q

Uses of Zarfirlukast

A

prophylaxsis of mild asthma

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15
Q

Two uses of Dinoprostone

A

cervical ripening in pregnancy

abortion on early pregnancy

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16
Q

Mechanism of action for Dinoprostone for abortion:

A

uterine contractions via EP1/3 receptors

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17
Q

What happens when Dinoprostone acts on EP4 receptor?

A

promotes cervical ripening, also relaxes cervical smooth muscle

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18
Q

When Dinoprostone acts on EP1/3 receptor, what is it doing?

A

causing uterine contractions for an abortion

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19
Q

GI-Related (nausea, vomiting, diarrhea)
fever
uterine rupture: contraindicated in women having
history of cesarean section or other uterine surgery

A

Dinoprostone

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20
Q

Women who’ve had cesarean section or other urterine surgiers shouldn’t use:

A

Dinoprostone

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21
Q

Carboprost is what kind of PG analogue

A

PGF2alpha

22
Q

uses of Carboprost

A

2nd trimester aboriton

to control hemorrhage after delivery

23
Q

How does Carboprost cause an abortion?

A

stimulates uterine contractility by action at FP

receptors

24
Q

This drug stimulates uterine contractility by action of The FP receptors

A

Carbaprost

25
Q

the drug causes myometrial
contractions via FP receptors. This provide
hemostasis at the site of placenta formation.

A

Carbaprost

26
Q

Carbaprost will stop bleeding by:

A

causing myometrial conx via FP receptors

27
Q

Contraindications of Carbaprost

A

GI-Related (nausea, vomiting, diarrhea)
fever
uterine rupture: past cesearan or uterine surgery

28
Q

What two drugs should you not use if you’ve had cesarea

A

Carboprost and Dinoprostone

29
Q

Misoprostol is what kind of analgue

A

PGE1 analogue

30
Q

Uses of MIsoprostol

A

primarily used as “replacement therapy” for
prevention of ulcers caused by long-term
administration with NSAIDs

31
Q

primarily used as “replacement therapy” for
prevention of ulcers caused by long-term
administration with NSAIDs

A

Misoprostol

32
Q

Mechanism of Misoprostol

–what receptor does it act on?

A

suppresses gastric acid secretion by
stimulating EP3 receptors on parietal cells;
causes a decrease in cAMP
increase mucin and bicarbonate secretion
increase mucosal blood flow

33
Q

Adverse affect with Misoprostol

A

diarrhrea–commone

34
Q

Contraindicationof Misoprostol

A

pregancy

35
Q

Alprostadil is an analogue for

A

PGE1

36
Q

Uses for Alprostadil: 2 of them

A

ED

maintain patent ductus arteriosis

37
Q

increase in cAMP which relaxes smooth

muscle of corpus cavernosum

A

Alprostadil

38
Q

MEch of Alprostadil (ED)

A

increases cAMP–> relaxes smooth muscles of corpus cavernosum

39
Q

Mech of Alprostadil for patent ductus arteriosis

A

cAMP-mediated relaxation of ductus

arteriosus smooth muscle

40
Q

cAMP-mediated relaxation of ductus

arteriosus smooth muscle

A

Alprostadil

41
Q

side effect seen in neonates given Alprostadil

A

apnea

42
Q

Epoprostenol is what kind of analogue

A

PGI2 analogue

43
Q

primary pulmonary hypertension
rare, idiopathic disease mainly observed in
young adults; increased incidence in females
leads to right heart failure; frequently fatal;

A

Epoprostenol

44
Q

Epoprostenol is used for what?

A

tx pulmonary hypertension–rare, seen in femalse, can lead to Right heart Fail

45
Q

Mech of action of Epoprostenol?

A

cAMP-mediated dilation of pulmonary

artery vascular smooth muscle

46
Q

Adverse effects seen with Epoprostenol

A

nausea, vomiting, headache, flushing

47
Q

Bimatoprost is analogue for

A

PGF2alpha

48
Q

two uses of Bimatoprost

A

eyelashes

glaucoma

49
Q

How does Bimatoprost tx glaucoma?

A

increaes outflow of aqueous humor

50
Q

How does Bimatoprost increase eyelashes

A

increases length and duration eyelashes are in growth phase

51
Q

PGF2alpha agonists

A

Bimatoprost

52
Q

Side effect of Bimatoprost

A

excess, unwanted hair growth, brown iris

pigmentation, eye redness, itching

Block 2 Drugs (10 decks)

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