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Block 2 Drugs > Inflammation Drugs > Flashcards

Inflammation Drugs Flashcards

1
Q

Inhibit cytokines (TNF-a) - receptor analog

A

Etanercept

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2
Q

Etanecept acts by:

A

inhibiting TNF-alpha.. it’s a receptor analogue

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3
Q

These two anti-inflammatory drugs are used to treat Rheumatoid arthritis, Crohn’s

A

Etanercept, Infliximab

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4
Q

Inhibit cytokines (TNF-a) - monoclonal antibody

A

Infliximab

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5
Q

Infliximab is a

A

monoclonal antibody that inhibits TNF-alpha

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6
Q

What is the risk we run when tx with Infliximab?

A

risk infection

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7
Q

What is the risk we run when tx with Entanercept?

A

risk infeciton

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8
Q

Devilvery of Etanercept

A

IV

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9
Q

Delivery of Infliximab

A

IV

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10
Q

Competitive antagonist of leukotriene receptors

A

Zarfirlukast

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11
Q

inhibits the synthesis of leukotrienes

A

Zileuton

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12
Q

Zieluton is:

A

anti-inflammatory: will inhibit SYNTHESIS of LKs

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13
Q

zarfirlukast is:

A

anti-inflammarot: COMPETITIVE antagonist of leukotriene receptors

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14
Q

Anti-inflammatory: Given as a prophylaxis, chronic asthma (NOT for acute attacks)

A

Zileuton

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15
Q

Prophylaxis, chronic asthma (NOT for acute attacks) Does not inhibit LTB4

A

Zarfirlukast

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16
Q

Zarfirlukast is given to patients with:

A

chronic asthma as a prophylaxis.. not for acute attacks

17
Q

MOst widely used NSAID in world

A

aspirin

18
Q

How does aspirin works

A

inhibits cylcooxygenase thus inhibits production of PGs

19
Q

What drug will inhibit the production of PG’s

A

NSAIDs via inhibition of COX

20
Q

route of administration for Zieluton and Zarfirlukast

A

ORAL

21
Q

Inhibit cytokines, prostaglandins, leukotrienes, CAMs (At transcriptional level)

A

Steroids

22
Q

How do steroids prevent inflammatinos

A

They inhibit cytokines, PGs, LKs and CAMs at a transcriptional level

23
Q

two inflammatory cytokine inhibitors

A

Etanercept

Infliximab

24
Q

What are my two leukotriene antagonists

A

Zarfirlukast

Zieluton

25
Q

GC come fromt he

A

adrenal cortex

26
Q

GC will ______ cytokines

A

inhibit

27
Q

GC will inihbit:

A

PLA2, COX2, CAMS, cytokines

28
Q

what is our first line tx for chronic asthma

A

inhaled steroids

29
Q

5 lipoxygenase inhibitor

A

Zileuton… can’t make LK’s

30
Q

cys-leukotriene receptor antatoginst

A

Zarfirlukast

Block 2 Drugs (10 decks)

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