ImmunoPharm Drugs

Question 1

Prednisolone is what type of drug

Answer 1

corticosteroid

Question 2

The effects of Prednisolone

Answer 2

Lymphocytopenia, monocytopenia, prevent neutrophil adherence, inhibit chemotactic factors, interfere with macrophage antigen processing, block lympokines, inhibit Fc receptor binding

Question 3

Prenisolone is used to tx:

Answer 3

Auto-immune diseases, prevent allograft rejection

Question 4

Used to tx Auto-immune diseases and prevent allograft rejection (corticosteroid)

Answer 4

Prednisolone

Question 5

Side effects of Prednisolone

Answer 5

Suppresses of adrenal-pituitary axis

- acute adrenal insufficiency on abrupt withdrawl

Question 6

Side effects of this drug are: suppresses of adrenal-pituitary axis
- acute adrenal insufficiency on abrupt withdrawl

Answer 6

Prednisolone

Question 7

Contraindications of Prednisolone

Answer 7

Existing infection

Question 8

Lymphocytopenia and monocytopenia are an effect of which drug

Answer 8

prednisolone

Question 9

Prevents neutrophil adherence

Answer 9

prednisolone

Question 10

Azathioprine works by:

Answer 10

Inhibiting purine biosynthesis, De Novo and Salvage

Question 11

Inhibits purine biosynthesis, De Novo and Salvage

Answer 11

Azathioprine

Question 12

Azathiopine is what type of drug

Answer 12

cytotoxic agent

Question 13

Azathiopine is used for?

Answer 13

Some auto-immune diseases (rheumatoid arthritis), prevent allograft rejection

Question 14

Side effects of Azathiopine

Answer 14

Bone marrow suppression, GI toxicity, hepatic toxicity

Question 15

Azathiopine is metabolized to:

Answer 15

Metabolized to 6-mercaptopurine

Question 16

Metabolized to 6-mercaptopurine

Answer 16

Azathiopine

Question 17

you should not use prednisolone if..

Answer 17

you have an existing infection

Question 18

Cyclophosphamide is what type of drug

Answer 18

cytotoxic agent

Question 19

What tissue or organs do cyclophosphamide drugs

Answer 19

B cells

Question 20

Effects of Cyclophosphamide

Answer 20

Cross-links DNA (alkylating agent)

Question 21

Uses of Cyclophosphamide

Answer 21

for auto-immune disease

Question 22

side effects of cyclophosphamide

Answer 22

bone marrow suppresion

Question 23

Cytotoxic agent used for auto-immune disease

Answer 23

Cyclophosphamide

Question 24

Mechanisms of Methotrexate

Answer 24

Inhibits folate dependent purine synthesis

Question 25

Methotrexate is what type of drug?

Answer 25

cytotoxic agent

Question 26

Methotrexate is used to tx what?

Answer 26

auto-immune disease

Question 27

What are the side effects of Methotrexate?

Answer 27

hepatic toxicity

Question 28

Mycophenolate Mofetil is what type of drug?

Answer 28

cytotoxic drug

Question 29

Mycophenolate Mofetil works on which type of tissue?

Answer 29

Lymphocytes (very selective)

Question 30

Mycophenolate Mofetil mechanism:

Answer 30

Inhibits IMP dehydrogenase (necessary for De Novo purine synthesis). Lymphocytes can not make GMP via salvage.

Question 31

IMP Dehydrogenase is necessary for ________ of purines and is inhibited by __________

Answer 31

De Novo synthesis | Mycophenolate Mofetil

Question 32

Uses of Mycophenolate Mofetil

Answer 32

Auto-immune diseases (rheumatoid arthritis, refractory psoriasis), prevent renal allograft rejection (with cyclosporine and corticosteroids)

Question 33

This drug is good at tx autoimmune diseases like RA and refractory psoriasis and preventing renal allograft rejection

Answer 33

Mycophenolate Mofetil

Question 34

Mycophenolate Mofetil is used with _____ and _____ when taken to prevent renal allograft rejection

Answer 34

cyclosporine and cotricosteroids

Question 35

side effects of mycophenolate mofetil are:

Answer 35

Infection, leukopenia, anemia

Question 36

Infection, leukopenia, anemia are side effects of

Answer 36

mycophenolate mofetil

Question 37

Mycophenolate Mofetil are contraindicated in these three instances:

Answer 37

Pregnancy, GI disease, renal disease,

Question 38

This is a Pro-drug. More selective than azathioprine or methotrexate

Answer 38

Mycophenolate Mofetil

Question 39

Cyclosporine acts on:

Answer 39

T cells

Question 40

How does Cyclosporine have it's effect?

Answer 40

Binds to cyclophilin and inhibits Calcineurin from dephosphorylating NFAT -> no IL-2 production

Question 41

This drug prevents IL-2 production

Answer 41

Cyclosporine

Question 42

Uses of cyclosporine

Answer 42

some autoimmune disease and to prevent allograft rejection

Question 43

Side effects of Cyclosprorine

Answer 43

Nephrotoxicity (25-40%), hepatotoxicity

Question 44

Tacrolimus is what type of drug

Answer 44

Clyclosporine like

Question 45

Tacrolimus has it's effects by:

Answer 45

Binds FK-BP12 ->(then same as cyclosporine)

Question 46

Tacrolimus is used for:

Answer 46

some autoimmune disease and preventing allograft rejection but is 50-100xs more effective then cyclosporine

Question 47

Which is more effective; tacrolimus or cyclosporine

Answer 47

tacrolimus is 50-100xs more effective

Question 48

side effects of tacrolimus

Answer 48

nephrotoxicity and hepatotoxicity (but less so than cyclosporine)

Question 49

Sirolimus is used for:

Answer 49

Coat cardiac stents, some auto-immune diseases, prevent allograft rejection

Question 50

Sirolimus is what type of drug

Answer 50

cyclosporine like

Question 51

Drug used to coat cardiac stents, some auto-immune diseases, prevent allograft rejection

Answer 51

Sirolimus

Question 52

Sirolimus works on which cell/tissue?

Answer 52

T cells

Question 53

How does Sirolimus have it's effect?

Answer 53

Binds FK-BP12, but inhibits mTOR -> blocks G1 to S transition

Question 54

Which cyclosprorin like drug Binds FK-BP12, but inhibits mTOR -> blocks G1 to S transition

Answer 54

Sirolimus