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Block 2 Drugs > ImmunoPharm Drugs > Flashcards

ImmunoPharm Drugs Flashcards

1
Q

Prednisolone is what type of drug

A

corticosteroid

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2
Q

The effects of Prednisolone

A

Lymphocytopenia, monocytopenia, prevent neutrophil adherence, inhibit chemotactic factors, interfere with macrophage antigen processing, block lympokines, inhibit Fc receptor binding

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3
Q

Prenisolone is used to tx:

A

Auto-immune diseases, prevent allograft rejection

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4
Q

Used to tx Auto-immune diseases and prevent allograft rejection (corticosteroid)

A

Prednisolone

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5
Q

Side effects of Prednisolone

A

Suppresses of adrenal-pituitary axis

- acute adrenal insufficiency on abrupt withdrawl

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6
Q

Side effects of this drug are: suppresses of adrenal-pituitary axis
- acute adrenal insufficiency on abrupt withdrawl

A

Prednisolone

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7
Q

Contraindications of Prednisolone

A

Existing infection

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8
Q

Lymphocytopenia and monocytopenia are an effect of which drug

A

prednisolone

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9
Q

Prevents neutrophil adherence

A

prednisolone

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10
Q

Azathioprine works by:

A

Inhibiting purine biosynthesis, De Novo and Salvage

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11
Q

Inhibits purine biosynthesis, De Novo and Salvage

A

Azathioprine

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12
Q

Azathiopine is what type of drug

A

cytotoxic agent

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13
Q

Azathiopine is used for?

A

Some auto-immune diseases (rheumatoid arthritis), prevent allograft rejection

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14
Q

Side effects of Azathiopine

A

Bone marrow suppression, GI toxicity, hepatic toxicity

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15
Q

Azathiopine is metabolized to:

A

Metabolized to 6-mercaptopurine

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16
Q

Metabolized to 6-mercaptopurine

A

Azathiopine

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17
Q

you should not use prednisolone if..

A

you have an existing infection

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18
Q

Cyclophosphamide is what type of drug

A

cytotoxic agent

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19
Q

What tissue or organs do cyclophosphamide drugs

A

B cells

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20
Q

Effects of Cyclophosphamide

A

Cross-links DNA (alkylating agent)

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21
Q

Uses of Cyclophosphamide

A

for auto-immune disease

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22
Q

side effects of cyclophosphamide

A

bone marrow suppresion

23
Q

Cytotoxic agent used for auto-immune disease

A

Cyclophosphamide

24
Q

Mechanisms of Methotrexate

A

Inhibits folate dependent purine synthesis

25
Q

Methotrexate is what type of drug?

A

cytotoxic agent

26
Q

Methotrexate is used to tx what?

A

auto-immune disease

27
Q

What are the side effects of Methotrexate?

A

hepatic toxicity

28
Q

Mycophenolate Mofetil is what type of drug?

A

cytotoxic drug

29
Q

Mycophenolate Mofetil works on which type of tissue?

A

Lymphocytes (very selective)

30
Q

Mycophenolate Mofetil mechanism:

A

Inhibits IMP dehydrogenase (necessary for De Novo purine synthesis). Lymphocytes can not make GMP via salvage.

31
Q

IMP Dehydrogenase is necessary for ________ of purines and is inhibited by __________

A

De Novo synthesis

Mycophenolate Mofetil

32
Q

Uses of Mycophenolate Mofetil

A

Auto-immune diseases (rheumatoid arthritis, refractory psoriasis), prevent renal allograft rejection (with cyclosporine and corticosteroids)

33
Q

This drug is good at tx autoimmune diseases like RA and refractory psoriasis and preventing renal allograft rejection

A

Mycophenolate Mofetil

34
Q

Mycophenolate Mofetil is used with _____ and _____ when taken to prevent renal allograft rejection

A

cyclosporine and cotricosteroids

35
Q

side effects of mycophenolate mofetil are:

A

Infection, leukopenia, anemia

36
Q

Infection, leukopenia, anemia are side effects of

A

mycophenolate mofetil

37
Q

Mycophenolate Mofetil are contraindicated in these three instances:

A

Pregnancy, GI disease, renal disease,

38
Q

This is a Pro-drug. More selective than azathioprine or methotrexate

A

Mycophenolate Mofetil

39
Q

Cyclosporine acts on:

A

T cells

40
Q

How does Cyclosporine have it’s effect?

A

Binds to cyclophilin and inhibits Calcineurin from dephosphorylating NFAT -> no IL-2 production

41
Q

This drug prevents IL-2 production

A

Cyclosporine

42
Q

Uses of cyclosporine

A

some autoimmune disease and to prevent allograft rejection

43
Q

Side effects of Cyclosprorine

A

Nephrotoxicity (25-40%), hepatotoxicity

44
Q

Tacrolimus is what type of drug

A

Clyclosporine like

45
Q

Tacrolimus has it’s effects by:

A

Binds FK-BP12 ->(then same as cyclosporine)

46
Q

Tacrolimus is used for:

A

some autoimmune disease and preventing allograft rejection but is 50-100xs more effective then cyclosporine

47
Q

Which is more effective; tacrolimus or cyclosporine

A

tacrolimus is 50-100xs more effective

48
Q

side effects of tacrolimus

A

nephrotoxicity and hepatotoxicity (but less so than cyclosporine)

49
Q

Sirolimus is used for:

A

Coat cardiac stents, some auto-immune diseases, prevent allograft rejection

50
Q

Sirolimus is what type of drug

A

cyclosporine like

51
Q

Drug used to coat cardiac stents, some auto-immune diseases, prevent allograft rejection

A

Sirolimus

52
Q

Sirolimus works on which cell/tissue?

A

T cells

53
Q

How does Sirolimus have it’s effect?

A

Binds FK-BP12, but inhibits mTOR -> blocks G1 to S transition

54
Q

Which cyclosprorin like drug Binds FK-BP12, but inhibits mTOR -> blocks G1 to S transition

A

Sirolimus

Block 2 Drugs (10 decks)

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