Ca++ Channel Blocker Flashcards
Phenylalkyamine uses
Angina, HTN, supraventricular arrhythmias (SA and AV nodes)
Contraindications of Phenylalkyamines
CHF, AV block, B-blockers
Phenylalkyamines work best in the CV or vascular smooth muscles?
High cardiac to vascular ratio (low bioavailability)
What state of the channel do phyenlyalkamines bind>
Use dependent binding (open state)
Verapamil uses
Angina, HTN, supraventricular arrhythmias (SA and AV nodes)
Verapamil is what type of Ca++ channel blocker
Phynlyalkyamine
Contraindications in Verapamil
CHF, AV block, B-blockers
Benzothiazipines uses
Angina, HTN, subrapventricular arrhythmias (SA and AV nodes)
What state do Benzothiazipines bind in?
the open state, use dependent
Side effect of Bensothiazipine
constipation
Benzothiazpines are contraindicated in which cases?
CHF, AV block, B-blockers
Benzothiazipines are more effective in the heart and Smooth vascular muscle
CV
Diltiazem is what type of drug
Benzothiazipine
Diltiazem is used for
Most used for Angina (reduces cardiac workoad, by decreasing SA node firing (low HR), reduce afterload via vasodilation
Side effect of diltiazem
Constipation
Diltiazem is most potent in CV or VSM
CV
Contraindications of Diltiazem
CHF, AV block, B-blockers
1,4-Dihydropyridines
Most used for HTN (potent vasodilatory)
Side effects 1,4 Dihydropyridines
Reflex tachycardia, hypotension, headaches
1,4-dihydropyridines act on the channel in which state?
Voltage dependent binding (inactivated state)
1,4-dihydropyridines is more potent in the CV or VSM
VSM
Nifedipine works when Ca++ channel is in what state?
Voltage dependent binding (inactivated state)
Nifedipine works in cardiac or VSM
High vascular to cardiac ratio
Uses of Nifedipine
for HTN~ it’s a potent vasodialatory
