Ca++ Channel Blocker

Question 1

Phenylalkyamine uses

Answer 1

Angina, HTN, supraventricular arrhythmias (SA and AV nodes)

Question 2

Contraindications of Phenylalkyamines

Answer 2

CHF, AV block, B-blockers

Question 3

Phenylalkyamines work best in the CV or vascular smooth muscles?

Answer 3

High cardiac to vascular ratio (low bioavailability)

Question 4

What state of the channel do phyenlyalkamines bind>

Answer 4

Use dependent binding (open state)

Question 5

Verapamil uses

Answer 5

Angina, HTN, supraventricular arrhythmias (SA and AV nodes)

Question 6

Verapamil is what type of Ca++ channel blocker

Answer 6

Phynlyalkyamine

Question 7

Contraindications in Verapamil

Answer 7

CHF, AV block, B-blockers

Question 8

Benzothiazipines uses

Answer 8

Angina, HTN, subrapventricular arrhythmias (SA and AV nodes)

Question 9

What state do Benzothiazipines bind in?

Answer 9

the open state, use dependent

Question 10

Side effect of Bensothiazipine

Answer 10

constipation

Question 11

Benzothiazpines are contraindicated in which cases?

Answer 11

CHF, AV block, B-blockers

Question 12

Benzothiazipines are more effective in the heart and Smooth vascular muscle

Answer 12

CV

Question 13

Diltiazem is what type of drug

Answer 13

Benzothiazipine

Question 14

Diltiazem is used for

Answer 14

Most used for Angina (reduces cardiac workoad, by decreasing SA node firing (low HR), reduce afterload via vasodilation

Question 15

Side effect of diltiazem

Answer 15

Constipation

Question 16

Diltiazem is most potent in CV or VSM

Answer 16

CV

Question 17

Contraindications of Diltiazem

Answer 17

CHF, AV block, B-blockers

Question 18

1,4-Dihydropyridines

Answer 18

Most used for HTN (potent vasodilatory)

Question 19

Side effects 1,4 Dihydropyridines

Answer 19

Reflex tachycardia, hypotension, headaches

Question 20

1,4-dihydropyridines act on the channel in which state?

Answer 20

Voltage dependent binding (inactivated state)

Question 21

1,4-dihydropyridines is more potent in the CV or VSM

Answer 21

VSM

Question 22

Nifedipine works when Ca++ channel is in what state?

Answer 22

Voltage dependent binding (inactivated state)

Question 23

Nifedipine works in cardiac or VSM

Answer 23

High vascular to cardiac ratio

Question 24

Uses of Nifedipine

Answer 24

for HTN~ it’s a potent vasodialatory

Question 25

What are the side effects of Nifedipine

Answer 25

Reflex tachycardia, hypotension, headaches

Question 26

Amlodipine is used for

Answer 26

hypertension

Question 27

Amlodipine works on which part of the body

Answer 27

more in the VSM

Question 28

Amlodipine is short of long lasting

Answer 28

long lasting

Question 29

Side effects of amlodipine

Answer 29

Reflex tachycardia, hypotension, headaches… but LESS reflex tachycardia d/t long lasting effects