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Block 2 Drugs > Renin-Angiotensin Lecture > Flashcards

Renin-Angiotensin Lecture Flashcards

1
Q

Aliskiren acts on which receptor?

A

renin

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2
Q

How does Aliskiren work?

A

Blocks renin from converting Angiotensinogen to Ang1

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3
Q

Which drug blocks renin from converting Angiotensinogen to Ang1

A

Aliskiren

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4
Q

side effects of aliskiren?

A

hypotension

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5
Q

Contraindications of Aliskiren?

A

Pregnancy

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6
Q

Losartan acts on which kind of receptor

A

AT1 antagonist

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7
Q

Blocks AT1 effects, and causes more AT2 stimulation

A

Losartan

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8
Q

Losartan blocks which receptor

A

AT1

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9
Q

Side effects of Losartan:

A

Takes 4-6 wks to work, do not increases dose if results are not immediate

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10
Q

Contraindication of Losartan

A

pregnancy

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11
Q

Captopril works on receptor how?

A

ACE inhibitor

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12
Q

3 ACE inhbitors

A

Captopril
Enalapril
Lisinopril

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13
Q

Block ACE from converting Ang1 to Ang2, and from catabolzing bradykinin.

A

ACE inhibitors

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14
Q

Mechanism of Captopril

A

Block ACE from converting Ang1 to Ang2, and from catabolzing bradykinin.

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15
Q

Mechanism of Enalapril

A

Block ACE from converting Ang1 to Ang2, and from catabolzing bradykinin.

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16
Q

Mechanism of Lisinopril

A

Block ACE from converting Ang1 to Ang2, and from catabolzing bradykinin.

17
Q

Side effects of ACE inhibitors

A

Angioedema, Hyperkalemia (as ANG2 stimulates Aldosterone). Cough (bradykinin)

18
Q

Side effects of Captopril, Enalapril, Lisinopril

A

Angioedema, Hyperkalemia (as ANG2 stimulates Aldosterone). Cough (bradykinin)

19
Q

Angioedema, Hyperkalemia (as ANG2 stimulates Aldosterone). Cough (bradykinin) are side effects are:

A

Captopril, Enalapril, Lisinopril

20
Q

Contraindications of ACE inhibitors

A

Pregnancy

21
Q

Which ACE inhibitor is short acting and needs to be taken 3xs/day

A

Captopril

22
Q

Which ACE inhibitors are long acting and can be taken 1x/day

A

Enalapril, Lisinopril

23
Q

Spironolactone is what kind of drug

A

mineralcorticoid antagonist

24
Q

Which 2 drugs are mineralcorticoid drugs

A

Spironolactone and Eplerenone

25
Q

Which receptor does Eplerenone work on?

A

renal/aldosterone receptor

26
Q

Uses of Eplerenone

A

Diuretic, HTN, heart failure

27
Q

Uses of Spironolactone

A

Diuretic, HTN, heart failure

28
Q

Which receptor does Eplerenone work on?

A

aldosterone renal receptor

29
Q

What receptor does Spironolactone work on?

A

aldosterone renal receptor

30
Q

What are the uses of Eplerenone and Spironolactone?

A

diuretics, HTN and for heart failure

31
Q

B1, B2 adrenergic antagonist

A

Propranolol

32
Q

Receptor that propranolol acts on

A

B1 and B2

33
Q

Effects of Propranolol

A

Decrease HR, decrease renin release

34
Q

Uses of Propranolol

A

to treat hypertension

35
Q

Metoprolol is used to tx

A

hypertension

36
Q

Metoprolol acts on which receptor

A

B1

37
Q

Metoprolol works by:

A

Decrease HR, decrease renin release

Block 2 Drugs (10 decks)

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