Slide 9

Question 1

Mutation rate in humans

Answer 1

1.5 for every million bases
1.5*10^-8 per base pair/haploid genome

Question 2

Why do humans have low mutation rates despite larger genomes than most organisms

Answer 2

Proof reading activity of DNA polymerase

Question 3

Exons or Introns get transcribed?

Answer 3

Exons

Question 4

Example of reverse transcription

Answer 4

HIV

Question 5

(T/F) a single amino acid can be coded by multiple sequences

Answer 5

True. Think of genetic redundancy

Question 6

_____ mutation may or may not alter the AA protein

Answer 6

Point

Question 7

Four major classes of genetic mutation

Answer 7

Point mutations
- single nucleotide changes
Frame shift mutations
- insertion, deletion
Chromosomal rearrangements
- large scale
Gene duplications

Question 8

5 structural mutations

Answer 8

1. Deletion
2. Duplication
3. Inversion
4. Fission
5. Fusion

Question 9

Polyploidy

Answer 9

A condition in which a cell or organism has more than two paired homologous sets of chromosomes

Question 10

Which of the five structural mutations led to humans to have 23 chromosome pairs while chimps have 24?

Answer 10

Fusion