Slide 8

Question 1

Describe the direction of DNA replication

Answer 1

3’ -> 5’ of TEMPLATE strand

5’ -> 3’ of new strand

Question 2

Helicase function

Answer 2

Unwind DNA

Question 3

Define mutation

Answer 3

Permanent change in DNA. Ultimate source of all genetic variation

Question 4

Which enzyme has proof reading activity?

Answer 4

DNA polymerase (III)

Question 5

Some genetic diseases cause errors in proof reading mechanisms. Name two

Answer 5

Lynch syndrome (colon cancer), Xeroderma pigmentosum

Question 6

Which of the two mutations are passed onto future generations?

Gametic or Somatic

Answer 6

Gametic (during DNA replication in meiosis)

Question 7

Name two autosomal dominant and two autosomal recessive disease discussed in class

Answer 7

Dominant: Huntington’s disease, Williams Syndrome

Recessive: Cystic fibrosis, Tay-Sachs disease