Sleep Flashcards

0
Q

Purpose of Pittsburgh sleep quality inventory

A

overall sleep functioning questionnaire

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1
Q

Purpose of Berlin and Stop BANG questionnaires?

A

OSA sx checklist

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2
Q

Epworth questionnaire used for what?

What is the scale cut offs

A

subjective sleepiness,

scale > 10 sleepy; >18 very sleepy

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3
Q

Name the four sleep phases

A

Stage R (REM)
Stage N1 (drowsy twilight: stage 1)
Stage N2: light NREM
Stage N3/4: deep slow wave NREM sleep

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4
Q

What happens to REM sleep and slow wave stage N3 sleep throughout the night?

A

Increased REM time, decreased N3

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5
Q

BMI with increased risk of OSA?

A

BMI > 30 (mild obesity)

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6
Q

biochemical issue in narcolepsy

Genetic finding in narcolepsy/cataplexy?

A
decreased hypocretin (orexin)
genetics: HLA-DQB1-0602 (85% n/c pts are pos, so are 20% controls)
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7
Q

major sx of narcolepsy is ____ NOT ____

A

excessive daytime sleepiness NOT sleep attacks

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8
Q

what is cataplexy?

A

episodic weakness / loss of tone esp when excited / laughing

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9
Q

Abnormal levels on multiple sleep latency test for narcolepsy?

A
  1. < 8 min to fall asleep is pathological sleepiness

2. SOREM: number of REM onset sleep periods > 2 (of 5 naps)

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10
Q

What is the maintenance of wakefulness test used for?

A

Test of treatment effectiveness in narcolepsy: 40 min staying awake w/ eyes closed in chair x 4

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11
Q

Drugs for narcolepsy? (3)

A

Armodafinil (long acting), Modafinil, stimulants

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12
Q

Tx for cataplexy (2)

A

SSRI or Sodium oxybate

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13
Q

What is Kleine-Levin syndrome?

A

hypersomnolence disorder with hypersexuality, intermittent/periodic

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14
Q

What terrible disease can be assoc w/insomnia?

A

fatal familial insomnia: prion dz

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15
Q

REstless leg syndrome mainly a problem with what and what is tx besides iron supp

A

DA issue. use Dopamine agonists like Ropinirole, Pramipexole, Carbidopa/levodopa

16
Q

REM behavior disorder assoc w/ what?

A

alpha synucleinopathies: PD, Lewy body dementia, multiple system atrophy

17
Q

REM behavior disorder occurs in what % of pts w/ narcolepsy/cataplexy?

A

1/3

18
Q

Rem behavior sleep disorder MEDICINE caution in narcolepsy?

A

TCA, SSRI, MAOI can exacerbate RBD in narcolepsy

19
Q

Possible medication treatments for REM behavior sleep disorder?

A
  1. Clonopin
  2. Melatonin
  3. Pramipexole
20
Q

Med that sleepwalking is associated with

A

Zolpidem (Ambien)

21
Q

What stage of sleep does sleepwalking occur in?

A

nonREM: Stage 2/3

22
Q

Medicine with success in sleepwalking?

A

clonopin

23
Q

sleep terrors arise from what stage of sleep?

A

Stage N3 (beginning of slow wave sleep)