Clinical Neurophysiology Flashcards
TEst that determines distribution of sweating?
Thermoregulatory sweat test
what is quantitative sudomotor axon reflex testing (QSART)
test postganglionic sympathetic failure seen in small fiber neuropathies AND
excessive sweating in reflex sympathetic dystrophy
2 signs of SNS dysfunction during valsalva test?
- exaggerated drop in BP in early phase 2 as venous return drops b/c lack of vasoconstrix
- no overshoot of BP after relaxation due to increased venous return
How do you test parasympathetic function during valsalva?
You should get a reflex bradycardia as BP increases in final overshoot BP due to vagal tone. Absent in PNS dysfunction.
What should HR do w/ breathing and what does it test?
should increase with inspiration due to cardiovagal reflex
autonomic neuropathy with orthostasis, bradycardia, megaesophagus, megacolon, and congestive cardiomyopathy found in South America/Central America patients
Chagas’ disease from trypanosomiasis
dopamine beta hydroxylase deficiency
- what does it cause in adults (2 sx)
- what NT pattern do you see
- what chromosome
- what tx?
Increased dopamine, lack of NE
chromosome 9q34
causes ptosis, orthostatic hypotension
tx: L-DOPS which can be decarboxylated into NE instead
Dopamine hydroxylase deficiency causes what in neonates?
3Hys: hypothermia, hypoglycemia, hypotension episodes
Disease with hypohidrosis, decreased tear/saliva, GI dysmotility, impotence, severe lancinating pain in extremities, renal disease
Cause
Genetics?
Fabry’s
alpha galactosidase def
X-linked recessive
What is familial amyloid polyneuropathy caused by and what is the disease path and sx?
small fiber neuropathy due to transthyretin defect FAP1
causes pain/temp sensation loss, autonomic sx and CHF
Disease causing lack of sensitivity to pain?
Hereditary sensory and autonomic neuropathies (HSAN) particularly
Riley-Day syndrome: HSAN III autosomal recessive in Ashkenazi jews (familial dysautonomia)
Genetic cause of Riley Day?
autosomal recessive mutation in kappaBkinase complex assoc protein on chrom 9q31
Distinctive feature of Riley day? (2 sx/si)
absence of fungiform papillae on tongue and no overflow emotional tears
EEG frequencies: the order from slow to fast
Delta, Theta, Alpha, Beta
*Dig that awesome beat
Alpha freq EEG?
8-13
Theta freq EEG
4-7
Beta freq EEG
> 13
Delta freq EEG
<4
negative deflection on EEG means what
That the first input is positive compared to second
pos to neg is down
What is the layout of bipolar montage?
inputs 1 and 2 are adjacent:
Channel 1: Fp1-F3
Channel 2: F3-C3
Channel 3: C3…
What is a referential montage?
There is a reference electrode that is presumably inactive
Channel 1: Fp1-Cz
Channel 2: F3-Cz
Channel 3: C3-Cz
Hyperventilation shouldn’t be performed w/ EEG on which 3 (non resp dz)
- cerebrovascular dz
- sickle cell trait/dz
- moymoya
Normal EEG response to hypervent?
generalized background slowing
photic response w/ epileptiform discharges seen in what major epilepsy? Actual photoconvulsive response seen with what?
JME (photoparoxysmal response)
primary generalized epilepsy - pts can have seizure w/ photic