SLE- Calcineurin Inhibitors DI

Question 1

Calcineurin inhibitors used in SLE

Answer 1

Tacrolimus, voclosporin

Question 2

Tacrolimus is used where in SLE?

Answer 2

Proliferative LN alone or in combo with MMF

Question 3

Voclosporin route of administration

Answer 3

PO

Question 4

Voclosporin brand name

Answer 4

Lupkynis

Question 5

Voclosporin MoA

Answer 5

Decreases cytokine production and lymphocyte proliferation

Question 6

When to use voclosporin in SLE

Answer 6

Adjunct therapy in immunosuppressants in LN

Question 7

Voclosporin BBW

Answer 7

Infection and malignancy

Question 8

Voclosporin causes nephrotoxicity when?

Answer 8

eGFR <45ml/min/1.73m^2

Question 9

What should you NOT use with voclosporin?

Answer 9

CYC

Question 10

Voclosporin DDIs

Answer 10

3A4 interactions, including grapefruit juice

Question 11

Voclosporin and strong 3A4 inducers

Answer 11

Make it less effective

Question 12

Voclosporin and strong inhibitors

Answer 12

Increase concentrations

Question 13

Advantage of voclosporin over Benlysta

Answer 13

PO

Question 14

Advantage of Benlysta over voclosporin

Answer 14

No 3A4 interactions