Gout- Pegloticase DI Flashcards
1
Q
Pegloticase drug class
A
Uricase agent
2
Q
Pegloticase MoA
A
Converts uric acid into allantoin to be excreted
3
Q
Pegloticase dosing
A
8mg IV q2w over at least 2 hours
4
Q
Pegloticase BBW
A
Infusion-related reactions (anaphylaxis and infusion reactions during and after therapy within the first 2 hours)
5
Q
How to prevent infusion reactions while taking pegloticase
A
Premeditate with antihistamines and corticosteroids
Gout prophylaxis with low-dose colchicine or NSAID x6 months
6
Q
Pegloticase indication
A
Chronic gout refractory to conventional treatment- aka it’s not first line
